A method for constructing schizophrenia gene-gene interaction network

Abstract

The invention discloses a method for constructing a schizophrenia gene-gene interaction network. The construction method comprises the following steps: ① collecting known candidate genes for schizophrenia; ② mapping the collected known candidate genes for schizophrenia In the human protein-protein interaction network, it is converted into an interaction network named after genes; ③ assign R-score to all genes in the network, assign G-score to all genes in the network, and assign weights to each edge ; ④ Construct the shortest path matrix between nodes; Extract the preliminary network with the "walk expansion" method; ⑤ Extract the final network and output the result. The present invention constructs the gene-gene interaction network of schizophrenia, removes some false positive genes, and includes more potential candidate genes related to schizophrenia. The enrichment analysis results show that the retained genes are more closely related to schizophrenia. Correlation indicates that the quality of the gene interaction network constructed by the present invention is better.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a schizophrenia gene-gene interaction network and a construction method thereof. Background technique [0002] Schizophrenia is a heritable psychiatric disorder characterized by positive and negative manifestations and symptoms and cognitive dysfunction that usually begins in early adulthood and often persists throughout life. In recent years, the research hotspots of schizophrenia mainly focus on the search of candidate genes for pathogenicity. These research results show that schizophrenia has a high degree of genetic heterogeneity. [0003] The traditional method of finding risk genes in disease signaling pathways is to detect protein-protein interactions, such as the study of DISC1. However, for schizophrenia, which has a large number of disease-causing genes, it is not only inefficient to conduct functional studies on individual genes, but also has to be done. Infor...

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Problems solved by technology

[0003] The traditional method of finding risk genes in disease signaling pathways is to detect protein-protein interactions, such as the study of DISC1. However, for schizophrenia, which has a large number of disease-causing genes, it is not only inefficient to conduct functional studies on individual genes, but also has to be done. information about the coordination and interaction between genes

There are also some studies that have mapped mutations to the KEGG signaling pathway and found that risk genes are enriched in the cell adhesion molecule pathway, but the signaling pathway does not act alone, and many other molecular pathways will also participate in it, and the pathogenic mechanism of most of the current mutations is not known. It is unclear and no one has systematically studied the pathogenic pathways of schizophrenia caused by mutations in pathogenic candidate genes of schizophrenia

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