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A kind of hap-csa-sf composite gel material and its preparation method and application

A technology of composite gel and composite gel layer, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor toughness, low support performance, weak cartilage and bone integration, etc., and achieve high toughness and good effect Effect

Active Publication Date: 2020-11-24
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing SF scaffold materials have poor toughness and low support performance
In addition, in the current repair process, the transition between cartilage and bone tissue is often ignored, resulting in an unstable bond between cartilage and bone after repair.

Method used

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  • A kind of hap-csa-sf composite gel material and its preparation method and application
  • A kind of hap-csa-sf composite gel material and its preparation method and application
  • A kind of hap-csa-sf composite gel material and its preparation method and application

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preparation example Construction

[0045] In one or more specific embodiments of the present invention, the preparation method of the above-mentioned HAp-CSA-SF composite gel material is provided, and the preparation method includes the preparation by acid-soluble alcohol-solid method, specifically including:

[0046] Preparation of HAp: Mix oleic acid and ethanol, add calcium salt solution, then add lye, then add sodium hydrogen phosphate solution, stir, and react at high temperature.

[0047] Preparation of CSA-SF compound acid solution: prepare silk fibroin formic acid solution, add chondroitin sulfate to silk fibroin formic acid solution.

[0048] In one or more specific embodiments of the present invention, the preparation method also includes placing the CSA-SF composite mixed acid solution into a mold carrying HAp, and the HAp-CSA-SF composite gel is obtained after the acid solution is volatilized and cooled. Material.

[0049] In one or more specific embodiments of the present invention, the preparatio...

Embodiment

[0065] Experimental materials and methods:

[0066] (1) Preparation and characterization of HAp-CSA-SF high toughness gel material

[0067] 1. Degumming 2.55g anhydrous NaCO 3 Add it into boiling deionized water, wait for it to dissolve completely, pour 3g of chopped silkworm shells into it, stir and heat for 30min, take out the degummed silk, wash it with deionized water 2-3 times, soak it overnight, take it out, and keep it at room temperature to dry.

[0068] 2. Preparation of short HAp nanowires

[0069] First mix 8ml of oleic acid and 10ml of absolute ethanol, then add 147mg of CaCl 2 2H 2 O aqueous solution (6ml), then added 0.5g of NaOH aqueous solution (8ml), then added 156mg of NaH 2 PO 4 2H 2 O aqueous solution (4ml), stirred for 10min. Finally, react in an oven at 180°C for 12h. After washing with absolute ethanol, short HAp nanowires were obtained.

[0070] 3. Dissolving Weigh 0.2~1g of anhydrous calcium chloride, dissolve it in 10~15ml 88% formic acid, p...

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Abstract

The invention provides a HAp-CSA-SF composite gel material. The HAp-CSA-SF composite gel material comprises a chondroitin-sulfate silk-fibroin composite gel layer, as well as a hydroxyapatite-enrichedlayer arranged on at least one end face of the chondroitin-sulfate silk-fibroin composite gel layer; the hydroxyapatite-enriched layer is capable of repairing damaged inner-layer bone tissue, as wellas enhancing bonding strength between cartilages and adjacent bones, thereby ensuring that a repaired cartilage can function normally; and the chondroitin-sulfate silk-fibroin composite gel layer isintegrated gel made from chondroitin sulfate and silk fibroin. Moreover, along with degradation of the silk fibroin, the chondroitin sulfate can be synchronously released so as to further promote regeneration of cartilages, thereby realizing repair on the cartilages. By adopting a multiphase layered design, the HAp-CSA-SF composite gel material is capable of realizing rapid cartilage repair, as well as synchronously enhancing bonding strength between repaired cartilages and adjacent bones

Description

technical field [0001] The invention belongs to the technical field of cartilage tissue repair, and in particular relates to a HAp-CSA-SF composite gel material and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Cartilage tissue engineering is one of the important directions of tissue engineering. Cartilage plays an important role in the human body such as load bearing, power transmission and cushioning. The cartilage in the joints is the basis for maintaining the normal movement of the human body. However, cartilage wear and tear and cartilage damage caused by external forces occur from time to time, and can cause problems such ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/40A61L27/12A61L27/52A61L27/54A61L27/58
CPCA61L27/12A61L27/26A61L27/52A61L27/54A61L27/58A61L2300/232A61L2300/412A61L2300/604A61L2430/06C08L89/00C08L5/08
Inventor 葛少华马保金商玲玲刘宏
Owner SHANDONG UNIV
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