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Efficient and safe centrifugal process for sulfadoxine

A kind of sulfanilamide, centrifugal process technology, applied in centrifuges, springs/shock absorbers, vibration suppression adjustment and other directions, can solve major safety, affect the centrifugal quality of sulfanilamide, hidden dangers and other issues

Inactive Publication Date: 2020-02-07
CHANGSHU JINSHEN MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] We can see that in the whole process of preparing sulfonamide, it is necessary to use the centrifuge several times for centrifugal separation and dehydration process. Under the high-speed rotating centrifugation condition, the centrifuge will inevitably have the problem of eccentric vibration, which is in the actual production The manufacturing process will not only affect the centrifugation quality of sulfadoxine, but also a major safety hazard; with the applicant's continuous and dedicated research in the field of sulfadoxine preparation for many years, it is hoped that further research and development will be carried out on the centrifugation process of sulfadoxine

Method used

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  • Efficient and safe centrifugal process for sulfadoxine
  • Efficient and safe centrifugal process for sulfadoxine
  • Efficient and safe centrifugal process for sulfadoxine

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Embodiment Construction

[0016] The embodiment of the invention discloses a high-efficiency and safe centrifugation process for sulfonamide, which is prepared by cyclization reaction, chlorination reaction and finishing treatment. The cyclization reaction and finishing treatment both include a centrifugation process. It is completed in the high-efficiency and safe centrifugal separation device. The high-efficiency and safe centrifugal device includes the filter centrifuge body, and the four sides of the filter centrifuge body are respectively installed on the fixed base through spring socket installation components with eccentric adjustment function; among them, each spring sleeve The connection installation component includes an eccentric adjustment spring, a fixed locking screw, an inner sleeve tube integrally arranged on the fixed base, and an installation sleeve fixedly arranged on the upper mounting plate. The adjustment spring is set between the upper mounting plate and the fixed base and is loca...

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Abstract

The invention discloses an efficient and safe centrifugal process for sulfadoxine. Centrifugal procedures are finished in an efficient and safe centrifugal separation device; the efficient and safe centrifugal device comprises a filter centrifuge main body; the filter centrifuge main body is mounted on a fixed base through spring sleeving installation modules with an eccentric adjusting function at the periphery; each spring sleeving installation module comprises an eccentric adjusting spring, a fixed locking screw rod, an embedding base pipe integrally arranged on the fixed base, and a mounting sleeve fixedly arranged on an upper mounting plate; the mounting sleeves sleeve the outer peripheries of the embedding sleeves; the eccentric adjusting springs are arranged between the upper mounting plates and the fixed base, and are positioned at the inner peripheries of the embedding sleeves; and fixed locking screw rods are inserted in the eccentric adjusting springs for threaded locking fit with the internal of the fixed base. The efficient and safe completion of sulfadoxine centrifugal procedures in the preparation process can be reliably guaranteed; the long-time reliable operation of the centrifugal procedures is guaranteed; and meanwhile, potential safety hazards are prevented.

Description

technical field [0001] The invention belongs to the technical field of preparation of sulfonamide antibacterial drugs, and in particular relates to an efficient and safe centrifugation process for sulfonamide. Background technique [0002] Sulfadoxine, also known as Zhouxiao sulfonamide, sulfa-o-dimethoxine or 4-sulfa-5,6-dimethoxypyrimidine, is a white or off-white crystalline powder with a slightly bitter taste, odorless, and gradually changes color when exposed to light. Slightly soluble in water, methanol and ethanol, insoluble in ether, soluble in sodium hydroxide and dilute inorganic acids, belonging to sulfonamide antibacterial drugs. Sulfadoxine has the characteristics of long curative effect and low toxicity. It can treat general inflammations, such as upper respiratory tract infection pancreatitis, bacillary dysentery enteritis and skin infections, etc., and it has certain curative effect on the treatment of pulmonary tuberculosis and lymphatic tuberculosis when it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F16F15/067B04B7/00
CPCB04B7/00F16F15/067
Inventor 李涛徐盛杰
Owner CHANGSHU JINSHEN MEDICAL PROD CO LTD
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