Application of Thesium chinense granules in preparation of medicine for treating hyperthermia caused by bacterial infection

A technology for high fever and yeast infection, which is applied in the application field of medicine to achieve the effects of high safety, wide distribution and improved content uniformity

Active Publication Date: 2020-02-07
HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of Thesium chinense granules in preparation of medicine for treating hyperthermia caused by bacterial infection
  • Application of Thesium chinense granules in preparation of medicine for treating hyperthermia caused by bacterial infection
  • Application of Thesium chinense granules in preparation of medicine for treating hyperthermia caused by bacterial infection

Examples

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Effect test

Embodiment 1

[0029] Example 1 Bairui Granules

[0030] Prescription: dry thyme extract powder 1000g, microcrystalline cellulose 150g, mannitol 10g, hydroxypropyl cellulose 20g, magnesium stearate 40g, water 250g;

[0031] Preparation method: take thyme grass and add ethanol aqueous solution, add ethanol aqueous solution with volume percentage of 50% for the first time, add ethanol aqueous solution with volume percentage of 75% for the second time, extract 2 times in total, extract 2 hours each time, combine and extract liquid, filter, collect the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.20, and dry it under vacuum at 40°C to obtain dry powder of Thyme officinalis extract, take microcrystalline cellulose, mannitol and magnesium stearate, add the above Grass extract dry powder, and add 12g of hydroxypropyl cellulose, mix uniformly to obtain a mixed material; take 8g of hydroxypropyl cellulose and add it to water, mix evenly to obtain a binder solut...

Embodiment 2

[0032] Example 2 Bairui Granules

[0033] Prescription: dry thyme extract powder 1000g, microcrystalline cellulose 150g, mannitol 10g, hydroxypropyl cellulose 20g, magnesium stearate 40g, water 250g;

[0034] Preparation method: take thyme grass and add ethanol aqueous solution, add ethanol aqueous solution with volume percentage of 50% for the first time, add ethanol aqueous solution with volume percentage of 75% for the second time, extract 2 times in total, extract 2 hours each time, combine and extract liquid, filter, collect the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.20, and dry it under vacuum at 40°C to obtain dry powder of Thyme officinalis extract, take microcrystalline cellulose, mannitol and magnesium stearate, add the above Dry grass extract powder, mixed uniformly to obtain a mixed material; 20 g of hydroxypropyl cellulose was added to water, mixed uniformly to prepare a binder solution, added to the mixed material, gr...

Embodiment 3

[0035] Example 3 Bairui Granules

[0036] Prescription: dry thyme extract powder 1000g, microcrystalline cellulose 180g, mannitol 12g, hydroxypropyl cellulose 30g, magnesium stearate 30g, water 300g;

[0037] Preparation method: take thymegrass and add ethanol aqueous solution, add ethanol aqueous solution with volume percentage of 30% for the first time, add ethanol aqueous solution with volume percentage of 80% for the second time, extract 2 times in total, extract 2 hours each time, combine and extract liquid, filter, collect the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.17, and dry it under vacuum at 40°C to obtain dry powder of Thyme officinalis extract, take microcrystalline cellulose, mannitol and magnesium stearate, add the above Grass extract dry powder, and add 21g of hydroxypropyl cellulose, mix evenly to obtain a mixed material; take 9g of hydroxypropyl cellulose and add it to water, mix evenly to make a binder solution, a...

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Abstract

The invention relates to the field of new medical application of chemical substances, in particular to an application of Thesium chinense granules in preparing a medicine for treating hyperthermia caused by bacterial infection. The researches find that the Thesium chinense granules can effectively inhibit rat fever caused by escherichia coli and saccharomycetes, can be used as a candidate drug formammal pathogenic bacteria induced hyperthermia, and are wide in distribution, low in cost, simple in process and flow and high in safety as the drug raw materials come from natural plant raw materials.

Description

technical field [0001] The invention relates to the field of new medical applications of chemical substances, in particular to the application of Bairui Granules in the preparation of medicines for treating high fever caused by germs. Background technique [0002] Hyperthermia caused by bacterial or fungal interference is a relatively common disease in humans, pigs, and poultry. It is mainly caused by single or multiple bacterial infections. Hypohidrosis and other diseases, there is no specific treatment at present, and high fever can easily lead to damage to the central nervous system of the brain, thereby causing cerebral palsy. Most of the existing drugs for the treatment of high fever are western medicines, which have low safety and large side effects. It is necessary to develop new drugs with clear inhibition or treatment of high fever, especially natural heat phytochemicals, which have important theoretical significance and social value for the development and clinical...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/38A61K47/10A61K47/12A61K36/185A61P29/00A61P31/04A61P31/10
CPCA61K9/1652A61K9/1623A61K9/1617A61K36/185A61P29/00A61P31/04A61P31/10Y02A50/30
Inventor 管悦琴李洪梅罗雪峰
Owner HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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