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A kind of quercetin derivative nano-micelle and preparation method thereof

A technology of nano micelles and derivatives, applied in the field of medicine

Active Publication Date: 2022-04-12
QINGHAI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there is no report about the preparation of the product

Method used

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  • A kind of quercetin derivative nano-micelle and preparation method thereof
  • A kind of quercetin derivative nano-micelle and preparation method thereof
  • A kind of quercetin derivative nano-micelle and preparation method thereof

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Embodiment 1

[0068] Embodiment 1. Preparation of quercetin derivative nanomicelles of the present invention (also referred to as quercetin derivative micelles and prodrug micelles in the present invention)

[0069] The mixed micelles were prepared by thin film dispersion method. Weigh 120mg lecithin, 80mg sodium taurocholate, 20mg quercetin derivatives;

[0070] A quercetin derivative, lecithin, was dissolved in tetrahydrofuran; sodium taurocholate was dissolved in methanol. Wherein, tetrahydrofuran / methanol=2:1, V / V; the total volume of tetrahydrofuran and methanol is 3ml.

[0071] Then the tetrahydrofuran solution and the methanol solution were mixed evenly, and the organic solvent was removed by rotary evaporation at 40° C. to form a thin film. Place in a vacuum oven for later use, add 4 mL of PBS (pH 7.4) at 37°C for hydration for 5 minutes, and vortex for 10 minutes to obtain nanomicelles of the present invention.

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Abstract

The invention provides a quercetin derivative nano-micelle, including quercetin derivatives, lecithin, sodium taurocholate, etc.; the quercetin derivatives are 2-hydroxyl-4-(3,5,7 -Trihydroxy-4-oxo-4H-benzopyran-2-yl)phenyl dodecanoate. The quercetin derivative nano micelles prepared by the invention have better encapsulation efficiency and drug loading capacity, and higher bioavailability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, which belongs to the field of medicine. Background technique [0002] Quercetin is a flavonoid compound widely distributed in nature, and exists in large quantities in common plants and vegetables and fruits, such as berries, tea, apples, onions, etc. Quercetin not only has a unique role in cardiovascular disease, cancer prevention and anti-cancer, but also can improve the tumor microenvironment, including reducing the multidrug resistance of tumor cells and competitively inhibiting related metabolic enzymes. Therefore, it has become a research focus of domestic and foreign scholars. [0003] In the Chinese patent application CN110128385A, a method for preparing a quercetin derivative - 2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-benzopyran-2- base) phenyl dodecanoate to obtain high-purity quercetin derivatives, which chemically modify natural quercetin, and through the substitution reaction at the 4'...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/352A61K47/28A61K47/24A61P35/00A61P9/00
CPCA61K9/1075A61K31/352A61K47/28A61K47/24A61P35/00A61P9/00
Inventor 马玉花林鹏程保怡潘国庆
Owner QINGHAI UNIV FOR NATITIES
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