Fixing and suturing method for preventing wound skin shrinkage of rodents and application of fixing and suturing method

Abstract

The invention provides a fixing and suturing method for preventing wound skin shrinkage of rodents and an application of the fixing and suturing method. The method comprises the following steps of annularly cutting off dartos of which the width is 2-3mm along the wound margins of the wound skin of the rodents, enabling the outer diamter of a steel ring to coincide with the edge of the cut-off dartos, and fixing the stell ring, the skin, the dartos and subcutaneous tissue in a suturing manner by a continuous hemstitch suturing method. The fixing and suturing method is notable in shrinkage preventing effects, can reduce the shrinkage of wound surfaces of rats to the maximum extent without influencing epithelium creepage, and does not influence the healing quality of the wound surfaces. A shrinkage preventing model prepared by the method can effectively simulate a wound healing mechanism, can accurately assess the crust creepage process of the wound healing process, can well observe the derma remodeling process, can be used as a good model for researching the wound healing, and can be used as a platform for assessing various factors influencing wound healing. The method has high application value in the respect of scientific research.

Description

technical field [0001] The invention specifically relates to a fixing and suturing method for preventing rodent wound skin from contracting and its application. Background technique [0002] The skin is the largest organ of the human body, accounting for about 5% to 15% of the body weight, with a total area of ​​1.5 to 2 square meters. The skin covers the surface of the whole body and is a natural barrier between the human body and the external environment. On the one hand, it can prevent the loss of water, electrolytes and other substances in the body, and on the other hand, it can also protect various tissues and organs in the body from physical, chemical and mechanical damage. Invasion of sex and pathogenic microorganisms. The skin is mainly divided into the epidermis and the dermis, and is connected with the deep tissue by the subcutaneous tissue. There are skin appendages such as hair, sebaceous glands, and sweat glands in the dermis, so the skin has the functions of ...

AI Technical Summary

Problems solved by technology

However, the existing problems are long-term treatment time required for long-term dressing change after debridement, high cost, heavy family burden, poor curative effect, and postoperative wounds are prone to infection, etc.

④The incidence of spontaneous tumors is low

However, in the practice of specific research, it is found that the anti-shrinkage method of the silicone ring has the following shortcomings: First, there is no uniform standard for the specifications of the silicone ring, and its anti-shrinkage performance will change due to the thickness, softness and hardness of the silicone ring. May become an additional interference factor affecting the experiment itself during the experimental research process

Third, the silicone ring is fixed on the surface of the animal's skin, and most of the sutures are also exposed. Larger and soft animals can bite the silicone ring and sutures, causing the silicone ring to deform or break, thus affecting anti-shrinkage Effect

Fourth, the silicone ring itself is a heterogeneous material, and the gap between it and the skin after suture is easy to hide dirt and dirt. Prolonged contact with the wound surface may cause wound infection and increase the risk of wound non-healing

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