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A kind of modified liposome and its composition, preparation method and application

A liposome composition and liposome technology, applied in the directions of botanical equipment and method, application, animal repellent, etc., can solve the problem of poor conduction effect, poor vesicle stability, unfavorable liquid deposition, etc. problem, to achieve the effect of excellent field control effect, low contact angle, and good wrapping ability

Active Publication Date: 2021-07-20
YANGZHOU SPED CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem of poor conduction effect on the target of pesticide adjuvants in the prior art, poor vesicle stability, and unfavorable deposition of medicinal liquid on the target, the present invention utilizes glycerophospholipids, sterols, polyols and cyclic Oxygen compounds are used as raw materials to synthesize modified liposomes, and the modified liposomes are used to prepare a kind of liquid that is easy to disperse in water, has good vesicle stability, is easy to biodegrade, and has stable properties. It has good conduction effect on the target and can benefit the medicinal liquid Deposit on the target, an adjuvant that can be widely used in the field of pesticides

Method used

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  • A kind of modified liposome and its composition, preparation method and application
  • A kind of modified liposome and its composition, preparation method and application
  • A kind of modified liposome and its composition, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method of the modified liposome in the present embodiment, comprises the following steps:

[0039] 835g soybean oil containing 10% phospholipids, 130g cholesterol, 25g glycerol, 10g diethanolamine, 6.78g KOH (catalyst) were put into an alkoxylation reactor, and the nitrogen was replaced three times. Raise the temperature to 95-105°C for dehydration for 1 hour, then control the temperature to 120-150°C, feed 1261g of ethylene oxide (EO), control the feed temperature at 100-150°C, and the maximum feed pressure is less than 0.4MPa; the feed is completed . Curing at 120-150°C, when the curing pressure is close to 0.02MPa, nitrogen gas is introduced to keep the pressure at 0.15-0.25MPa. When the pressure in the reactor remains constant, the reaction ends; the aging time is about 1-2 hours. At 120-135°C, vacuumize for 0.5-1h, cool down to 70-80°C, add neutralizing reagent HAc to adjust the pH to 5-7. After the reaction is finished, the modified liposome pro...

Embodiment 2

[0045] Put 835g soybean oil containing 30% phospholipids, 130g cholesterol, 25g glycerol, 10g diethanolamine, and 6.78g KOH into an alkoxylation reaction kettle, and replace nitrogen three times. Raise the temperature to 95-105°C for dehydration for 1 hour, then control the temperature to 120-150°C, feed 1261g of EO, control the feed temperature at 100-150°C, and the maximum pressure of the feed is less than 0.4MPa; the feed is complete. Curing at 120-150°C, when the curing pressure is close to 0.02MPa, nitrogen gas is introduced to keep the pressure at 0.15-0.25MPa. When the pressure in the reactor remains constant, the reaction ends; the aging time is about 1-2 hours. At 120-135°C, vacuumize for 0.5-1h, lower the temperature to 70-80°C, add neutralizing reagent phosphoric acid to adjust the pH to 5-7. After the reaction is finished, the modified liposome product is obtained, and the sample is recorded as Example 2.

[0046] Weigh 89.2g of the sample of Example 2, together ...

Embodiment 3

[0048] Put 835g soybean oil containing 50% phospholipids, 130g cholesterol, 25g glycerol, 10g diethanolamine, and 6.78g KOH into an alkoxylation reaction kettle, and replace nitrogen three times. Raise the temperature to 95-105°C for dehydration for 1 hour, then control the temperature at 120-150°C, feed 1261g of EO, control the feed temperature at 100-150°C, and the maximum pressure of the feed is less than 0.4MPa; the feed is complete. Curing at 120-150°C, when the curing pressure is close to 0.02MPa, nitrogen gas is introduced to keep the pressure at 0.15-0.25MPa. When the pressure in the reactor remains constant, the reaction ends; the aging time is about 1-2 hours. At 120-135°C, vacuumize for 0.5-1h, lower the temperature to 70-80°C, add neutralizing reagent phosphoric acid to adjust the pH to 5-7. After the reaction is finished, the modified liposome product is obtained, and the sample is recorded as example 3.

[0049] Weigh 89.2 g of the sample of Example 3, together...

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Abstract

The invention belongs to the field of pesticide adjuvants, and provides a modified liposome, a composition, a preparation method and an application. The modified liposome is put into the reaction kettle under the action of a catalyst, and the mixture of glycerophospholipids, sterols and polyhydroxy compounds is used as a starter, and the temperature is raised for dehydration, and then ethylene oxide is passed through to carry out ring-opening polymerization and aging. , neutralized, and the polyhydroxy compound is a combination of alcohols and alcohol amines. The present invention also provides a liposome composition prepared from modified liposomes, which has the advantages of easy dispersion in water, good vesicle stability, easy biodegradation, and stable properties when used as a pesticide adjuvant. The advantages of good conduction effect and the ability to facilitate the deposition of liquid medicine on the target can be widely used in the field of pesticides.

Description

technical field [0001] The invention relates to the field of pesticide adjuvants, in particular to a modified liposome and its composition, preparation method and application. Background technique [0002] Liposomes are spherical bodies formed by dispersing phospholipids and additives in water. It is both hydrophilic and hydrophobic, and can wrap both water-soluble drugs and fat-soluble drugs. Water-soluble drugs are encapsulated in the water layer structure of liposomes, while fat-soluble or amphipathic drugs are encapsulated in lipophilic part of liposomes or lipid bilayers. Liposomes are similar to cell structures and have the characteristics and functions of biological membranes, so they are also called artificial biological membranes. The liposome dosage form has the characteristics of targeting, sustained release, low toxicity, low residue, non-toxic to organisms, and no side effects. [0003] At present, liposome research has been widely carried out in various phar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/08A01N25/10A01N25/30
CPCA01N25/08A01N25/10A01N25/30
Inventor 王磊宋文勇曹雄飞秦敦忠陈世国
Owner YANGZHOU SPED CHEM
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