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Application of EGCG in preparation of preparation for preventing and/or treating PRV infection and preparation for preventing and/or treating PRV infection

A preparation and gallate technology, applied in the field of porcine pseudorabies virus infection treatment, can solve the problem of no effective treatment measures for mutant PRV, and achieve the effects of no toxic side effects, less environmental pollution, and easy availability of raw materials

Active Publication Date: 2020-01-31
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no effective treatment for mutated PRV in my country, and the occurrence of the disease can only be controlled by early prevention and strengthening health management.

Method used

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  • Application of EGCG in preparation of preparation for preventing and/or treating PRV infection and preparation for preventing and/or treating PRV infection
  • Application of EGCG in preparation of preparation for preventing and/or treating PRV infection and preparation for preventing and/or treating PRV infection
  • Application of EGCG in preparation of preparation for preventing and/or treating PRV infection and preparation for preventing and/or treating PRV infection

Examples

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Effect test

Embodiment 1

[0031] A preparation for preventing and / or treating porcine pseudorabies virus infection, which is obtained by dissolving epigallocatechin gallate in 0.1mol / L PBS buffer solution, and the concentration of epigallocatechin gallate is 50mmol / L L.

Embodiment 2

[0033] A preparation for preventing and / or treating porcine pseudorabies virus infection, which is obtained by dissolving epigallocatechin gallate in 0.15mol / L PBS buffer solution, and the concentration of epigallocatechin gallate is 40mmol / L L.

Embodiment 3

[0035]A preparation for preventing and / or treating porcine pseudorabies virus infection, which is obtained by dissolving epigallocatechin gallate in 0.1mol / L PBS buffer solution, and the concentration of epigallocatechin gallate is 100mmol / L L.

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Abstract

The invention provides application of epigallocatechin gallate (EGCG) in preparation of a preparation for preventing and / or treating porcine pseudorabies virus infection and a preparation for preventing and / or treating porcine pseudorabies virus, and belongs to the technical field of treatment of porcine pseudorabies virus infection. The concentration of the EGCG in the medicine is 10 to 100 micromole / L. In the invention, the anti-porcine pseudorabies virus infection effect of the EGCG has is extremely remarkable: the EGCG can reduce cytopathic effect caused by porcine pseudorabies virus, theadsorption, cell entry and replication of the porcine pseudorabies virus are inhibited, the porcine pseudorabies virus can be directly killed, more importantly, the EGCG can prevent and / or treat miceinfected by the porcine pseudorabies virus, and a scientific and reliable theoretical basis is provided for clinical treatment of the porcine pseudorabies virus.

Description

technical field [0001] The invention belongs to the technical field of porcine pseudorabies virus infection treatment, in particular to the application of epigallocatechin gallate in the preparation of preparations for preventing and / or treating porcine pseudorabies virus infection and the preparation for preventing and / or treating porcine pseudorabies virus . Background technique [0002] Porcine pseudorabies virus is a linear double-stranded DNA molecule belonging to the family Herpesviridae and the genus Porcine Herpesvirus. Pseudorabies virus is pantropic and can proliferate in a variety of tissue culture cells, among which rabbit kidney and pig kidney cells (including the original first-generation cells and second-generation cell lines) are the most sensitive and cause obvious cytopathic changes. Pigs are the storage hosts of pseudorabies virus, and sick pigs, infected pigs and infected rodents are the main sources of infection for this disease. In pig herds, the viru...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P31/20
CPCA61K31/353A61P31/20
Inventor 郇长超徐伟音郭停停高崧
Owner YANGZHOU UNIV
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