Method of noninvasively calculating personalized coronary artery branch blood flow reserve capacity

Abstract

The invention provides a method of noninvasively calculating personalized coronary artery branch blood flow reserve capacity, and belongs to the field of biomedical engineering. The method includes the steps: cardiac ultrasound data is adopted to obtain the flow of a coronary artery at a resting state; on the basis of coronary artery CT image files, a coronary artery three-dimensional model is rebuilt, and the length, volume and opening cross-section area of a coronary artery branch are measured; then, according to coronary artery fractal coefficients and allometry laws, a flow distribution method based on the opening cross-section area of the coronary artery branch is built, in combination with resistance mathematical models corresponding to coronary artery stenosis segments and coronaryartery non-stenosis segments, the pressure of a coronary artery distal outlet is obtained, and through hydrodynamics, coronary artery distal outlet flow taking stenosis effects into account is calculated; and finally, according to the relationship that the flow of the coronary artery at a maximum congestion state is 3 times that of the coronary artery at the resting state, coronary artery distal outlet flow at the maximum congestion state is obtained, and by comparing a threshold value of 3 with the ratio of the coronary artery blood flow at the maximum congestion state and the coronary arteryblood flow at the resting state, the coronary artery branch blood flow reserve capacity is determined.

Description

technical field [0001] The invention proposes a method for non-invasively calculating personalized coronary artery branch blood flow reserve capacity, which belongs to the technical field of biomedical engineering and relates to a method for noninvasively calculating coronary artery branch blood flow reserve capacity from rest to maximum hyperemia state. Background technique [0002] With the development of ultrasound imaging technology, the blood flow reserve capacity of coronary artery branches is qualitatively described from rest to maximum hyperemia state by comparing the cardiac wall motion in rest and exercise tests. The commonly used methods for simulating the state of maximum coronary congestion include exercise load and drug load. [0003] (1) Exercise load is to simulate the state of maximum coronary hyperemia by increasing myocardial oxygen consumption through treadmills or active plates. By comparing the motion of the heart wall at rest and maximum hyperemia, qua...

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Problems solved by technology

Although drug loading can be used to simulate the maximum coronary artery hyperemia state for those who cannot exercise, it cannot quantitatively study the blood flow reserve capacity of coronary artery branches from rest to maximum hyperemia state

[0005] Although ultrasonography can non-invasively evaluate coronary artery branch blood flow reserve capacity, it cannot quantitatively study coronary artery branch blood flow reserve capacity from rest to maximal hyperemia

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