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Extraction and refining method of polygonatum polysaccharide

The technology of polysaccharide polysaccharide and refining method of Polygonatum polysaccharides is applied in the field of extraction technology of Polygonatum chinensis extract, which can solve the problems of many types of impurities, complicated refining process, low product rate and the like, and achieve the effect of increasing the screening effect.

Active Publication Date: 2020-01-14
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention provides a method for extracting and refining Polygonatum Polysaccharides in order to solve the problems that the existing Polygonatum Polysaccharides extraction method has many types of impurities, complex refining process, long process flow and low product rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0025] 1) Leaching to obtain feed liquid; Polygonatum raw material is dried, pulverized, and passed through an 80-mesh sieve to obtain Polygonatum granules. Take 100g of Polygonatum granules, add 2L of distilled water, stir and heat to 75°C, keep warm and extract for 30 minutes to obtain a feed liquid, at this time, the concentration of Polygonatum polysaccharide in the feed liquid reaches 0.3g / L.

[0026] 2) Membrane extraction to obtain the extract; use nanofiltration membrane modules for membrane extraction, wherein the nanofiltration membrane is a hydrophobic membrane material with a membrane pore size of 20nm, a membrane area of ​​about 0.5㎡, a molecular weight cut-off of 25KD, and an extraction agent of 2L ethyl acetate , and 10 g of 1-methylbenzeneboronic acid was added to the extractant, the circulation flow of the extractant was 200 mL / min, and the side of the extractant was maintained at normal pressure. The feed liquid is circulated on the shell side of the membrane...

specific Embodiment approach 2

[0029] The difference between the specific embodiment 2 and the specific embodiment 1 is that the nanofiltration membrane is a hydrophilic membrane material, the membrane pore size is 20nm, the membrane area is about 0.5 square meters, and the molecular weight cut-off is 25KD. The rest of the treatment and treatment conditions are the same as the specific embodiment 1. , The purity of the polysaccharide solid obtained in the specific embodiment 2 is 90%, and the yield is 95%.

specific Embodiment approach 3

[0031] The difference between specific embodiment 3 and specific embodiment 1 is that the temperature on the side of the extractant is 40 ° C, and the rest of the treatment and treatment conditions are the same as specific embodiment 1. The purity of the polysaccharide solid obtained in specific embodiment 3 is 91%, and the yield was 89%.

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Abstract

The invention relates to an extraction and refining method of polygonatum polysaccharide, belonging to the technical field of extraction processes of polygonatum extracts. The method of the inventionsolves the problems of a plurality of impurity types, complex refining process, long technological process and low product rate in conventional polygonatum polysaccharide extraction methods. Accordingto the method, a membrane extraction technology and a complexing extraction technology are combined; organic boric acid is adopted as a complexing agent of polygonatum polysaccharide at an extractionagent side, the organic boric acid and the polysaccharide are subjected to specific complexing, polar polygonatum polysaccharide is changed into a non-polar complex through a complexing reaction, andcomplexing extraction is conducted, so the purpose of separation is achieved; and after the complexing extraction is finished, the complexing action and an organic solvent are removed through back extraction so as to obtain a high-purity polygonatum polysaccharide product. During membrane extraction in the invention, the combined action of membrane extraction and complexing extraction is realized; namely, besides separation through polarity difference in the membrane extraction process, the screening action of a membrane is added.

Description

technical field [0001] The invention relates to a method for extracting and refining Polygonatum polysaccharides, and belongs to the technical field of extraction technology of Polygonatum extract. Background technique [0002] Polygonatum is a traditional Chinese medicine in my country, which belongs to the homology of medicine and food. Polygonatum mainly contains Polygonatum polysaccharides, saponins, niacin, quinones, amino acids and trace elements, etc., and has various pharmacological effects such as delaying aging, enhancing immune function, regulating blood lipids, lowering blood sugar, and anti-tumor. Studies have shown that Polygonatum Polysaccharides is the main active ingredient in Polygonatum Polysaccharides, which is a mixture of polysaccharides, generally containing acidic polysaccharides, neutral polysaccharides and glycoproteins, etc. These polysaccharides usually use galactose as the main constituent unit. Polygonatum polysaccharides are rich in content, u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
CPCC08B37/0003
Inventor 王建勋侯同刚咸漠荀明月董晴晴刘仲舒
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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