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Pediatric trauma spray and preparation method thereof

A spray and trauma technology, which is applied in the field of medicine, can solve the problems of unfitness for children, slow wound healing, and large wound irritation.

Active Publication Date: 2020-01-10
JILIN UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional methods are more irritating to the wound, and the wound healing speed is relatively slow, which is not suitable for pediatric patients.

Method used

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  • Pediatric trauma spray and preparation method thereof
  • Pediatric trauma spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Pediatric Trauma Spray 1

[0032] Weigh 1g of 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol , borneol 0.5g, p-methoxyoctyl cinnamate 1g, isopropanol 5g, methyl ethyl ketone 5g, Tween 80 1g, edetate disodium 0.5g and purified water 90g, prepare this implementation according to the following method Pediatric Trauma Spray as described in the example:

[0033] 1) 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-alcohol and Grind borneol into fine powder, add it to the mixture of isopropanol and methyl ethyl ketone and stir well;

[0034] 2) Take 65% by weight of purified water, add octyl p-methoxycinnamate, Tween 80 and disodium edetate to it, and place it in a vortex mixer to oscillate and mix evenly after adding;

[0035] 3) Add the mixture obtained in step 1) to the mixed solution obtained in step 2) in batches under stirring, and place it in a vortex mixer to oscillate and mix evenly after the addition;

[0036] 4)...

Embodiment 2

[0039] Pediatric Trauma Spray 2

[0040] Weigh 2g of 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol , borneol 1g, p-methoxyoctyl cinnamate 2.5g, isopropanol 7.5g, methyl ethyl ketone 7.5g, Tween 802.5g, edetate disodium 1g and purified water 100g, prepare this product according to the following method Pediatric trauma spray described in embodiment:

[0041] 1) 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-alcohol and Grind borneol into fine powder, add it to the mixture of isopropanol and methyl ethyl ketone and stir well;

[0042] 2) Take 65% by weight of purified water, add octyl p-methoxycinnamate, Tween 80 and disodium edetate to it, and place it in a vortex mixer to oscillate and mix evenly after adding;

[0043] 3) Add the mixture obtained in step 1) to the mixed solution obtained in step 2) in batches under stirring, and place it in a vortex mixer to oscillate and mix evenly after the addition;

[0044] 4) Add the ...

Embodiment 3

[0047] Pediatric Trauma Spray 3

[0048] Weigh 3g of 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-ol , borneol 1.5g, p-methoxyoctyl cinnamate 5g, isopropanol 10g, methyl ethyl ketone 10g, Tween 80 5g, edetate disodium 1.5g and purified water 110g, prepare this implementation according to the following method Pediatric Trauma Spray as described in the example:

[0049] 1) 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborol-1-alcohol and Grind borneol into fine powder, add it to the mixture of isopropanol and methyl ethyl ketone and stir well;

[0050] 2) Take 65% by weight of purified water, add octyl p-methoxycinnamate, Tween 80 and disodium edetate to it, and place it in a vortex mixer to oscillate and mix evenly after adding;

[0051] 3) Add the mixture obtained in step 1) to the mixed solution obtained in step 2) in batches under stirring, and place it in a vortex mixer to oscillate and mix evenly after the addition;

[0052]...

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Abstract

The invention discloses a pediatric trauma spray and a preparation method thereof. The pediatric trauma spray is prepared from 5-chloro-7-(3-hydroxy-propoxy)-3-nitromethyl-3H-benzo[c][1,2]oxaborocyclopentadien-1-ol, borneol, octyl 4-methoxycinnamate, isopropanol, methyl ethyl ketone, Tween 80, disodium edetate and purified water, is in a solution form, and has an excellent function of promoting healing of traumatic wounds of children, especially hemorrhagic traumatic wounds.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a trauma spray for children and a preparation method thereof. Background technique [0002] Trauma refers to the destruction of the anatomical structure of tissues or organs and the disorder of physiological functions caused by external causes. Trauma generally includes stab wounds, abrasions, bruises, crushes, lacerations, burns, sprains, animal bites, etc. [0003] Children aged 1 to 6 are at the highest risk of accidental injuries because they are full of curiosity and exploratory spirit about things in the surrounding environment, and at the same time lack the experience of judging danger and the ability to protect themselves when danger comes. Such accidental injuries are often manifested as trauma in the form of bleeding wounds on the skin due to damage from various mechanical factors. Bleeding wounds usually imply a breach of the integrity of the skin and other associat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/14A61K47/10A61K47/08A61K47/26A61K47/18A61K31/33A61K31/045A61P17/02
CPCA61K9/0014A61K9/12A61K31/045A61K31/33A61K47/08A61K47/10A61K47/14A61K47/183A61K47/26A61P17/02A61K2300/00
Inventor 陶娜王园园宫春梅
Owner JILIN UNIV FIRST HOSPITAL
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