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Devices and methods for diagnosis of sinusitis

A hand-held device, nostril technology, applied in the direction of biochemical equipment and methods, diagnosis, measurement devices, etc., can solve the problem that the patient cannot be fully guided

Active Publication Date: 2020-01-03
ENTVANTAGE DIAGNOSTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing sampling devices, including swabs and other such devices, may not adequately guide the patient to the proper location within the sinus for sample extraction

Method used

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  • Devices and methods for diagnosis of sinusitis
  • Devices and methods for diagnosis of sinusitis
  • Devices and methods for diagnosis of sinusitis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0184] Example 1 (Lysis Buffer)

[0185] Such as Figure 27 As indicated, different lysis buffers were tested to determine the time to successfully lyse cells corresponding to Haemophilus influenzae (H.flu), Moraxella catarrhalis (M.cat) and Streptococcus pneumoniae (S.pneumo). Optimal buffer composition. Some potential candidates tested included N-lauroyl sarcosine, Triton X100, sarcosyl, sarcosyl and sucrose, and Bugbuster (Novogen). The effectiveness of each of these buffers was tested using standardized samples of known concentrations of H. influenzae, M. catarrhalis and S. pneumoniae. Based on the lysis data, the sucrose and sarcosyl lysis buffer components appear to be the most efficient at lysing all three cell types. Importantly, many combinations (including combinations that do not contain sarcosyl and sucrose) do not work with all three cell types and, therefore, may not be compatible with combination assays that detect all three cell types.

[0186]Therefore, ...

example 2

[0188] Example 2 (wiping material selection)

[0189] Experiments to test the best swab material for sampling were also performed. Because the area where the sample is to be collected (the subject's nasal and sinus cavities) is a rather sensitive area, it is important to be able to quickly and efficiently collect enough sample material for the assay. Also, it is desirable to sample the subject's nasal and sinus cavities only once, as repeated sampling can result in irritation of the subject's nasal and sinus cavities. Also, any attempt to collect a sample after the first attempt may elicit an autonomic response of excess mucus in the nasal passages, which may dilute the collected sample or blood. While materials such as cotton swabs and gauze can be used, two commercially available swab materials were tested for their ability to obtain samples quickly. Hydraflock, Ultraflock and Purflock were tested for their ability to absorb water, ATS-M (Manual Test Soil) laboratory soi...

example 3

[0191] Example 3: Test method

[0192] After sampling using the device described above for the collection device, insert the swab with the sample into the lysis buffer by fully extending the end of the swab and inserting into the appropriate volume of lysis buffer, as in Figure 26 shown. In this example, the positive end of the swab goes into the tube with the lysis buffer (the swab can be a sample device swab such as Figure 25K shown). The swab can be mixed or agitated in the buffer and removed (eg, after 1-30 seconds). Bacteria can be lysed in the sample buffer by the action of the lysis buffer. See for lysis buffer ( Figure 28 ) and dilution buffer ( Figure 29 ) of the example Figure 28 and Figure 29 . The sample buffer can then be applied directly to the assay, or it can be diluted (e.g. 1:10) in a lysis buffer or a second buffer (dilution buffer, such as Tris buffer), which can aid in wicking on the membrane. 100-200 microliters of sample can then be loa...

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Abstract

Apparatuses for sampling mucous from within a sinus to determine if a single sample includes one or more bacterial types indicating bacterial sinusitis comprising an indicator to guide the angle at which a user inserts the apparatus relative to the patient.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 477,889, filed March 28, 2017, entitled "DEVICES AND METHODS FOR DIAGNOSISOF SINUSITIS." [0003] incorporated by reference [0004] All publications and patent applications mentioned in this specification are herein incorporated by reference in their entirety to the extent that each individual publication or patent application was specifically and individually indicated to be incorporated by reference. technical field [0005] The present application relates to methods and devices for determining the presence of one or more pathogens associated with bacterial sinusitis from collected mucus samples, and preferably to the three or more pathogens associated with over 90% of bacterial sinusitis Detection of more pathogens. Background technique [0006] Sinusitis, defined as inflammation of the sinus tissue, is usually a complication of a vira...

Claims

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Application Information

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IPC IPC(8): A61B10/02A61F13/38C12Q1/04G01N33/48G01N33/569
CPCA61B10/0045A61B2010/0006
Inventor J·斯科拉巴O·E·霍金斯M·雷贾斯卡兰A·西曼斯基R·巴希D·塞鲍尔
Owner ENTVANTAGE DIAGNOSTICS INC
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