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An improved low-toxic Zengsheng pharmaceutical composition and its preparation method and application

A composition and an improved technology, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems that the preparation method has not been reported in the literature, achieve important application value, reduce liver and kidney toxicity, and enhance the effect of safety

Active Publication Date: 2022-06-21
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports in the literature on the improved Zengshengping composition and its preparation method based on attenuation

Method used

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  • An improved low-toxic Zengsheng pharmaceutical composition and its preparation method and application
  • An improved low-toxic Zengsheng pharmaceutical composition and its preparation method and application
  • An improved low-toxic Zengsheng pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1. Preparation process 1 for removing toxic components

[0086] 100 g of xanthate japonica, 210 g of fresh white skin, add 3.1 L of water, heat and extract for two times, each for 2 hours, filter, combine the extracts, and concentrate under reduced pressure at 60°C to about 310 ml. Add about 310 ml of ethyl acetate, extract for three times in total, discard the organic phase, and take the aqueous phase as A. 420g of mountain bean root, 420g of ginseng, 420g of Beibei sauce, 420g of Prunella vulgaris, add 16.8L of water, heat and extract for a total of two times, each for 2 hours, filter, combine the extracts, and concentrate under reduced pressure at 60°C to about 1.68 L, for B. After A and B were mixed, freeze-dried, pulverized and weighed, and the calculated yield was 22%. Designated as ZSP-2.

Embodiment 2

[0087] Example 2. Preparation process 2 for removing toxic components

[0088] 100 g of xanthoxylum japonica and 210 g of fresh white skin were added with 3.1 L of water, heated and extracted twice, each for 2 hours, filtered, combined the extracts, and concentrated under reduced pressure at 60°C to about 310 ml. The concentrate was loaded onto the macroporous adsorption resin DiaionHP-20 (3.1L), eluted with 50% ethanol for 4 times the column volume, and the eluates were combined and concentrated under reduced pressure at 60°C to about 310ml, numbered as A. 420g of mountain bean root, 420g of ginseng, 420g of Beibei sauce, 420g of Prunella vulgaris, add 16.8L of water, heat and extract for a total of two times, each for 2 hours, filter, combine the extracts, and concentrate under reduced pressure at 60°C to about 1.68 L, numbered B. After A and B were mixed, freeze-dried and pulverized, and the calculated yield was 21%. Designated as ZSP-3.

Embodiment 3

[0089] Example 3. Preparation process 3 for removing toxic medicinal materials

[0090] 420g of mountain bean root, 420g of ginseng, 420g of Beibei sauce, 420g of Prunella vulgaris, add 16.8L of water, heat and extract for a total of two times, each for 2h, filter, combine the extracts, concentrate, freeze-dry and pulverize to obtain rate 23%. Designated as ZSP-4.

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PUM

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Abstract

The invention discloses a preparation method of an improved hypotoxic Zengshengping. It is characterized in that through extraction or resin refining, on the premise of not reducing the efficacy of the medicine, the toxic components that can cause severe liver damage in Zengshengping are targetedly removed. The improved low-toxicity Zengping composition prepared by this method can be used alone or in the form of a composition to prepare a pharmaceutical preparation for preventing and / or treating cancer, alone or in combination with pharmaceutically acceptable excipients, Various dosage forms are prepared according to conventional methods. It can be used for the treatment and / or prevention of various cancers, especially squamous cell carcinoma and potentially malignant lesions of the mucosa, as well as the treatment of proliferative diseases. The invention provides a safer and more effective preparation method for the clinically applied drug Zengshengping, and thus has a good application prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound composition for preventing and / or treating tumor diseases, in particular to an improved traditional Chinese medicine compound Zengpingping composition for reducing liver toxicity and its preparation method and use. Background technique [0002] Tumors, especially malignant tumors, are one of the most lethal diseases in human beings. At present, the treatment of malignant tumors is mainly based on surgery, radiotherapy and chemotherapy. However, many chemical anticancer drugs often involve normal cells when they act on target cells, resulting in serious side effects. The traditional Chinese medicine compound Zengpingping (CN1062656A, CN101966272A) is composed of six traditional Chinese medicines: Shandougen, Prunella vulgaris, Quanginseng, Beibei sauce, white fresh skin, and xanthate. It has the effects of clearing away heat and detoxifying, removing blood stasis and dispersing stasis. I...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P35/00A61P1/02A61P1/00A61P1/04A61P1/06A61P11/04A61P15/14A61P29/00A61P37/02
CPCA61K36/8945A61K36/75A61K36/489A61K36/704A61K36/28A61K36/536A61P35/00A61P1/02A61P37/02A61P1/04A61P1/00A61P15/14A61P29/00A61P1/06A61P11/04A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2300/00
Inventor 王素娟关晓兵王嘉祺包捷贺浩珂张森汪苑苑石建功
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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