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Preparation method of hydroxypropyl cyclodextrin included retinol

A technology of hydroxypropyl cyclodextrin and retinol, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as skin allergy and poor stability, and achieve prevention and Fine wrinkle, pigmentation lightening, fine wrinkle reduction effect

Inactive Publication Date: 2019-12-31
广州市博之越精细化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is very sensitive to light, heat, and high-priced metal ions, has poor stability, and is likely to cause skin allergies and other factors, it has not been widely used in the cosmetics industry.

Method used

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  • Preparation method of hydroxypropyl cyclodextrin included retinol
  • Preparation method of hydroxypropyl cyclodextrin included retinol
  • Preparation method of hydroxypropyl cyclodextrin included retinol

Examples

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Effect test

Embodiment 1

[0021] A preparation method of hydroxypropyl cyclodextrin inclusion retinol, comprising the following steps:

[0022] (1) Take 1 part of retinol, add 25 parts of purified water, heat to 70°C, stir for 1.5 hours to dissolve;

[0023] (2) Add 5 parts of hydroxypropyl cyclodextrin to the dissolved retinol solution, stir at 70° C. for 2 hours to make inclusion fully, and obtain hydroxypropyl cyclodextrin inclusion retinol.

Embodiment 2

[0025] A preparation method of hydroxypropyl cyclodextrin inclusion retinol, comprising the following steps:

[0026] (1) Take 1 part of retinol, add 15 parts of purified water, heat to 50°C, stir for 2 hours to dissolve;

[0027] (2) Add 8 parts of hydroxypropyl cyclodextrin to the dissolved retinol solution, stir at 50° C. for 4 hours to make inclusion fully, and obtain hydroxypropyl cyclodextrin inclusion retinol.

Embodiment 3

[0029] A preparation method of hydroxypropyl cyclodextrin inclusion retinol, comprising the following steps:

[0030] (1) Take 1 part of retinol, add 10 parts of purified water, heat to 40°C, stir for 2 hours to dissolve;

[0031] (2) Add 3 parts of hydroxypropyl cyclodextrin to the dissolved retinol solution, stir at 40° C. for 4 hours to make inclusion fully, and obtain hydroxypropyl cyclodextrin inclusion retinol.

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Abstract

The invention belongs to the technical field of cosmetic raw materials, and particularly discloses a preparation method of hydroxypropyl cyclodextrin included retinol. The method comprises the following steps of (1) taking 1 part of retinol, adding 10-30 parts of purified water, performing heating to 40-80 DEG C, and performing stirring for 0.5-2 hours to enable the retinol to dissolve; and (2) adding 3-10 parts of hydroxypropyl cyclodextrin to retinol alcosol which dissolves, and performing stirring at 40-80 DEG C for 1-4 hours, for sufficient inclusion, so as to obtain the hydroxypropyl cyclodextrin included retinol. The retinol is encapsulated with the hydroxypropyl cyclodextrin to obtain slow-release high-efficiency products, so that the biological availability of the retinol is improved, absorption by skin is facilitated, and the hydroxypropyl cyclodextrin included retinol can dissolve in water. The hydroxypropyl cyclodextrin included retinol not only has all of the efficacy of the retinol, but also can effectively prevent and reduce fine wrinkles, and the skin roughness is reduced. Stains are alleviated, and the hydroxypropyl cyclodextrin included retinol is stable and safe.

Description

technical field [0001] The invention belongs to the technical field of cosmetic raw materials, and in particular relates to a preparation method of hydroxypropyl cyclodextrin inclusion retinol. Background technique [0002] Retinol is fat-soluble and is an essential factor for regulating the growth and health of epithelial tissue cells. It can thin the surface of rough and aging skin and promote the normalization of cell metabolism. It is an eye care product with obvious wrinkle-removing effect. It can be used in advanced cosmetics such as anti-wrinkle and whitening. Retinol also helps cells reproduce and distinguish dead cells, and acts as an antioxidant that binds to free radicals that can cause genetic mutations. [0003] Retinol is also well known in the cosmetic industry for its very significant anti-aging and anti-wrinkle benefits. However, because it is very sensitive to light, heat, and high-priced metal ions, has poor stability, and is likely to cause skin allergi...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/73A61Q19/00A61Q19/08A61Q19/02
CPCA61K8/671A61K8/732A61Q19/005A61Q19/08A61Q19/02A61K2800/805
Inventor 敖德平
Owner 广州市博之越精细化工有限公司
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