Stepping drug delivery device

Abstract

The invention provides a stepping drug delivery device. The stepping drug delivery device comprises a bearing assembly, a drug delivery catheter, a line pipe, a threaded rod, a nut, a signal recorderand a connecting rod; the middle of the threaded rod is sleeved with a nut, the lower end of the threaded rod makes contact with an inner wall of a lower portion of the bearing assembly, and the upperend of the threaded rod penetrates through the upper portion of the bearing assembly and is provided with a driving structure; a limiting piece used for limiting rotation of the nut is further arranged in the bearing assembly so that the nut can move up and down when the threaded rod rotates; and when the nut moves up and down, the drug delivery catheter is driven to move up and down. According to the device, the stepping of the drug delivery catheter can be realized; therefore, dosing operation can be carried out on a larger area; according to the scheme, an electrode wire used for detectingneuron signals is additionally arranged on the drug delivery catheter, so that integration of drug delivery and signal detection is achieved, a drug delivery area can be detected in a targeted mode,signal acquisition is more timely and targeted, and therefore the acquired signals are more accurate.

Description

technical field [0001] The invention relates to the field of biomedical experiment devices, in particular to a step-by-step drug delivery device. Background technique [0002] In biological experiments, there are many methods of drug administration for experimental animals, such as intraperitoneal injection, intravenous injection, and gavage. However, for the study of brain nerves and brain diseases, the above administration methods have serious deficiencies: [0003] First, some drugs cannot pass through the blood-brain barrier and fail to achieve the expected effect; [0004] Second, the dosage is small, generally a few microliters or even less. [0005] The traditional way of drug administration for experimental animals is limited in targeting neurological and brain diseases. [0006] For this reason, a central nervous system administration method has also been developed, which is mostly used for the response of target nuclei or brain regions to drugs. At present, the ...

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Problems solved by technology

[0007] However, because the catheter is fixed in this way, it can only be administered to a fixed position, and one such device cannot be administered to multiple positions, and cannot achieve more comprehensive drug delivery; and the current method takes up Excessive volume, after implantation of catheters in the brain it is no longer possible to embed microelectrode arrays for signal recording, which makes accurate recording of neuronal electrical signals impossible, for example after acute drug administration

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