Probiotics microcapsule bacterial powder and preparation method and application thereof

A technology of probiotics and microcapsules, which is applied in the field of probiotic microcapsule powder and its preparation, can solve the problems of incomplete improvement effects and limited improvement methods, and achieve good physiological effects, good degradability, and improved living bacteria rate effect

Inactive Publication Date: 2019-12-24
CABIO BIOTECH WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned probiotic preparations in the prior art have improved the survival rate of probiotics from different angles, but the improvement methods are still limited, and the improvement effect is not very comprehensive. Therefore, a new type of probiotic preparation has been developed to make it significantly It is very meaningful to improve the activity and live bacteria rate of probiotics, and to be able to stably colonize the gastrointestinal tract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The present embodiment provides a kind of probiotic microcapsule bacterial powder, and described probiotic microcapsule bacterial powder comprises core material and wall material, and described core material is Bifidobacterium longum thalline, and described wall material is polysialic acid, solid Corn syrup and starch sodium octenyl succinate. Its preparation method is:

[0079] (1) Plant Bifidobacterium longum into the liquid medium for activation and proliferation, the culture temperature is 36°C, and the culture time is 35h. After reaching the mature and stable stage, the culture medium is centrifuged at 4000r / min for 10min at 10°C. , collect and obtain Bifidobacterium longum thalline; Wherein polysialic acid accounts for 10% of wall material, the ratio of solid corn syrup and starch sodium octenyl succinate is 3:1, and the mass ratio of thalline and wall material is 1: 4;

[0080] (2) Stir and mix the bacteria and wall material solution obtained in step (1) at 250 r...

Embodiment 2

[0083] The present embodiment provides a kind of probiotic microcapsule bacterial powder, and described probiotic microcapsule bacterial powder comprises core material and wall material, and described core material is Bifidobacterium longum thalline, and described wall material is polysialic acid, solid Corn syrup and starch sodium octenyl succinate. Its preparation method is:

[0084] (1) Plant Bifidobacterium longum into the liquid medium for activation and proliferation, the culture temperature is 36°C, and the culture time is 35h. After reaching the mature and stable stage, the culture medium is centrifuged at 5000r / min for 5min at 0°C , collect and obtain Bifidobacterium longum thalline; Wherein polysialic acid accounts for 20% of wall material, the ratio of solid corn syrup and starch sodium octenyl succinate is 10:1, and the mass ratio of thalline and wall material is 1: 1;

[0085] (2) Stir and mix the bacteria and wall material solution obtained in step (1) at 50°C ...

Embodiment 3

[0088] The present embodiment provides a kind of probiotic microcapsule bacterial powder, and described probiotic microcapsule bacterial powder comprises core material and wall material, and described core material is Bifidobacterium longum thalline, and described wall material is polysialic acid and solid corn syrup. Its preparation method is:

[0089] (1) Plant Bifidobacterium longum into the liquid medium for activation and proliferation, the culture temperature is 36°C, and the culture time is 35h. After reaching the mature and stable stage, the culture medium is centrifuged at 6000r / min for 15min at 10°C. , collecting and obtaining Bifidobacterium longum thallus; wherein polysialic acid accounts for 1% of the wall material, the adhesive in the wall material is solid corn syrup, and the mass ratio of the thalline to the wall material is 1:15;

[0090] (2) Stir and mix the bacteria and wall material solution obtained in step (1) at 300 r / min at 70°C for 30 minutes, and coo...

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Abstract

The invention relates to probiotics microcapsule bacterial powder and a preparation method and application thereof. The probiotics microcapsule bacterial powder is prepared from core materials and wall materials, the core materials comprise probiotics, and the wall materials comprise polysialic acid. The polysialic acid creatively serves as the wall materials of microcapsules, the probiotics serves as the core materials of the microcapsules, thus the polysialic acid and the probiotics can exert respective physiological functions and can also synergistically act, a probiotics preparation can exert better properties, and the bacterial survival rate of the probiotics is remarkably increased; the activity of the probiotics can also be improved; and meanwhile the probiotics can be smoothly colonized in the intestinal tract, and the physiological effect is exerted better.

Description

technical field [0001] The invention belongs to the field of biological technology, and in particular relates to a probiotic preparation and its preparation method and application, in particular to a probiotic microcapsule powder and its preparation method and application. Background technique [0002] Probiotics are a class of active microorganisms that are beneficial to the host. They are a general term for active beneficial microorganisms that colonize the human intestinal tract and reproductive system and can produce definite health effects, thereby improving the host's micro-ecological balance and exerting beneficial effects. It can be used as a kind of oral beneficial live bacteria preparation (health food requires that the total number of live bacteria in the shelf life is not less than 10 6 ), but in the process of production, transportation, storage, etc., probiotics will be affected by food components (acid, oxygen, additives, etc.), storage temperature, and host d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23P10/30
CPCA23L33/135A23P10/30
Inventor 汪志明李翔宇陆姝欢左摇肖敏胡雄
Owner CABIO BIOTECH WUHAN CO LTD
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