Sugar fine particle, preparation method, device and application thereof

A fine particle and particle size technology, applied in the field of fine sugar particles and its preparation, can solve the problems of poor fluidity of powdered sugar, unsmooth feeding, poor mixing, etc., to achieve favorable drug stability, save production costs, and improve solubility Good results

Active Publication Date: 2019-12-20
南京紫鸿生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary sucrose and crushed sugar powder cannot be directly compressed in one step in the production of tablets, that is, all raw and auxiliary materials are mixed evenly at one time and then compressed. Exist in the original granules in the tablet, which affects the appearance of the tablet and the performance of dissolution and disintegration; and after the sucrose is crushed into powdered sugar, although the dissolution performance is improved, the fluidity of the powdered sugar is very poor, and the mixing is poor. Unable to smoothly unload during tablet production, it is also impossible to compress uniform tablets
[0008] On the other hand, the sucrose products currently available for direct compression, such as compressible sucrose and sucrose spherical particles, all contain at least 2% of non-sucrose components, such as starch, dextrin, etc., because these components cannot be dissolved in water , and the quality requirement of the effervescent tablet preparation is to dissolve into a clear liquid in water, so the above-mentioned directly compressed sucrose products cannot be used in the prescription of effervescent tablets

Method used

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  • Sugar fine particle, preparation method, device and application thereof
  • Sugar fine particle, preparation method, device and application thereof

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Experimental program
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Effect test

Embodiment 1

[0043] The preparation of embodiment 1 sugar fine particle

[0044] Mix and pulverize 99.9:0.1 sucrose and glucose syrup powder to obtain powdered sugar with a particle size of 100 mesh. The obtained powdered sugar is blown up with hot air in the fluidized bed, and water is sprayed at the same time. The volume of the fluidized bed and the material The weight ratio is 10.75L / KG, the pressure of the water jet pump is 3 kg, and the hot air volume is 8000 cubic meters per hour. The prepared sugar fine particles have a particle size of 60 mesh, an apparent density of 0.53 g / ml, and an angle of repose of 32°.

Embodiment 2

[0045] The preparation of embodiment 2 sugar fine particles

[0046] The 99.5:0.5 sucrose and glucose syrup powder are mixed and pulverized to obtain powdered sugar with a particle size of 100 mesh. The obtained powdered sugar is blown up with a hot air flow in the fluidized bed, and water is sprayed at the same time. The volume of the fluidized bed and the material The weight ratio is 10.75L / KG, the pressure of the water jet pump is 5 kg, and the hot air volume is 8000 cubic meters per hour. The prepared sugar fine particles have a particle size of 70 mesh, an apparent density of 0.48 g / ml, and an angle of repose of 32°.

Embodiment 3

[0047] The preparation of embodiment 3 sugar fine particles

[0048] The 99.7:0.3 sucrose and glucose syrup powder are mixed and pulverized to obtain powdered sugar with a particle size of 100 mesh. The obtained powdered sugar is blown up with hot air in the fluidized bed, and water is sprayed at the same time. The volume of the fluidized bed and the material The weight ratio is 10.75L / KG, the pressure of the water jet pump is 8 kg, and the hot air volume is 5000 cubic meters per hour. The prepared sugar fine particles have a particle size of 100 mesh, an apparent density of 0.43 g / ml, and an angle of repose of 32°.

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Abstract

The present invention provides a sugar fine particle. The sugar fine particle has pores inside and is approximately spherical outside. The sugar fine particle is made of pure sucrose and glucose syruppowder with equal to or less than 0.5% as raw materials; and the sugar fine particle has a particle size of 30-100 meshes, an apparent density of 0.4-0.6 g / ml, and a repose angle of 30 degrees-35 degrees. The sugar fine particle has good fluidity, good solubility and good compressibility, and can be used as medicinal auxiliary materials for direct tabletting. The preparation method controls a ratio of fluidized bed volume to weight of the materials and pressure and hot air amount of a water jet pump to prepare the sugar fine particle capable of being used for the direct tabletting.

Description

technical field [0001] The invention belongs to the field of pharmaceutical excipients, and in particular relates to a fine sugar granule and a preparation method, equipment and application thereof. The fine sugar granule has pores inside and an approximate spherical shape outside. Background technique [0002] Sucrose is an important excipient in pharmaceutical preparations. It can be used as a sweetener and a filler for solid preparation tablets, and it plays the role of flavor correction and excipient. Sucrose is widely used in pharmaceutical preparations. At present, its application forms at home and abroad are as follows Several: [0003] 1. Crystalline sucrose: sucrose crystals, which are used as sweeteners, flavoring agents, fillers, binders, and coating materials for sugar-coated tablets in preparations. When used in tablets, it generally cannot be directly compressed, but needs to be crushed into powdered sucrose for use; [0004] 2. Sucrose powder: The sucrose po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/26A61K9/20B01J2/16F26B3/084
CPCA61K47/26B01J2/16F26B3/084A61K9/2018
Inventor 沈惠母泽波
Owner 南京紫鸿生物科技有限公司
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