Frozen-dried preparation containing regeneration factors and preparation method and application of frozen-dried preparation

Abstract

The invention discloses a frozen-dried preparation containing regeneration factors and a preparation method and application of the frozen-dried preparation. The frozen-dried preparation containing regeneration factors comprises a first frozen-dried preparation and a second frozen-dried preparation, wherein the first frozen-dried preparation comprises a frozen-dried product obtained by performing freezing-drying on a mixture of activated platelet rich plasma and an activator, and the second frozen-dried preparation comprises a frozen-dried product obtained by performing freezing-drying on platelet poor plasma; and the frozen-dried preparation comprises platelet plasma and platelet poor plasma, which are independently frozen-dried and activated, so as to well preserve functional factors andnutrient substances in the plasma, and prevent the activator from activating fibrinogen in the plasma in advance. The invention provides a preparation method of the frozen-dried preparation. The preparation method is simple in technology and short in consumption time, so that the frozen-dried preparation can be well utilized and preserved. The preparation method can be used for industrial batch production of the frozen-dried preparation containing the regeneration factors, can also be used for medical-care places so as to collect autoblood of patients, and is used for on-site making and using.

Description

technical field [0001] The invention relates to the technical field of biological products, in particular to a freeze-dried preparation containing regenerative factors, a preparation method and application thereof. Background technique [0002] As one of the main components in mammalian blood, platelets are biologically active small pieces of cytoplasm that are shed from the cytoplasmic lysis of mature megakaryocytes in the bone marrow. Platelet-rich blood (Platelet-rich plasma, PRP) is a platelet concentrate extracted from centrifuged blood. The main components are high concentration of platelets (the number is more than three times higher than that in whole blood), white blood cells and fibrin. Platelet-rich plasma (PRP) therapy is a regenerative repair technology, mainly used for tissue trauma repair, such as repair of difficult-to-heal fractures, bone defects, osteomyelitis, articular cartilage, tendon and ligament injuries, and difficult-to-heal wounds (such as pressure...

AI Technical Summary

Problems solved by technology

[0003] Although PRP has obvious effects in the treatment of difficult-to-heal wounds, it still has limitations such as not easy to store, easy to deteriorate and inactivate, inconvenient to use, and requires repeated blood draws and re-preparation every time it is used.

The current platelet-rich plasma (Platelet-rich plasma, PRP) has many disadvantages in clinical application, including: low growth factor content; difficult to preserve, blood must be collected for each treatment, and patients cannot use it by themselves when they leave the hospital; Restricted, etc.

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