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Ultrasonic contrast agent and preparation method thereof

An ultrasonic contrast agent and solution technology, applied in echo/ultrasonic imaging agents, pharmaceutical formulations, preparations for in vivo tests, etc., can solve problems such as limiting the application of plasma, achieve long stabilization time, reduce impurities, and have good use effects Effect

Active Publication Date: 2019-12-17
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inability of active radicals in the plasma to penetrate deeper tissues limits the application of plasma

Method used

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  • Ultrasonic contrast agent and preparation method thereof
  • Ultrasonic contrast agent and preparation method thereof
  • Ultrasonic contrast agent and preparation method thereof

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Embodiment 1

[0025] The invention relates to an ultrasonic contrast agent. The ultrasonic contrast agent is composed of a spherical wall, an inner gas and a solution; the spherical wall material includes Span 60, Tween 80, and polyethylene glycol; the inner gas is plasma The complex of body and inert gas; The solution formula is phosphate buffer;

[0026] The preparation process of the ultrasound contrast agent is as follows:

[0027] 1) Solution preparation: The configuration of phosphate buffer solution: Weigh 4.005g of NaCl, 0.097g of KCl, 1.145g of Na2HPO4 H2O, and 0.096g of KH2PO4 on an analytical balance, put them into a volumetric flask with a volume of 500ml, add deionized water to Make up to 500ml for later use.

[0028] 2) Weigh 1.487g of Span 60, 0.230g of polyethylene glycol, and 1.500g of sodium chloride into a beaker with a volume of 150ml on an analytical balance, then add 50ml of deionized water, put it on a magnetic stirrer and add it while stirring Tween 80 1ml forms a ...

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Abstract

The invention discloses an ultrasonic contrast agent and a preparation method thereof, and belongs to the technical field of ultrasonic imaging. The contrast agent is composed of a spherical wall, aninner gas and a solution. The spherical wall is made of Span 60, Tween 80 and polyethylene glycol; the inner gas is a composition of plasma and inert gas; and the solution is a phosphate buffer solution. The ultrasonic contrast agent has good response to ultrasound for clinical diagnosis, and plasmas in the inner gas can be released through ultrasonic mediation and is used for killing tumor cellsin a targeted mode. Ultrasonic diagnosis and treatment are combined. A diseased part is locked through ultrasonic contrast, then ultrasonic stimulation is applied, and treatment under the guidance ofultrasonic images is conducted. The treatment efficiency is improved while the pain of a patient is relieved. In addition, the ultrasonic contrast agent has the advantages of long stabilization time,good using effect and long circulating half-life period.

Description

technical field [0001] The invention belongs to the field of contrast agents, and in particular relates to an ultrasonic contrast agent and a preparation method thereof. Background technique [0002] As an important revolution in the development of ultrasound medicine, ultrasound contrast agents have greatly improved the application and development of ultrasound medicine. Ultrasound contrast agent is a kind of encapsulated microbubbles with a diameter of several hundred nanometers to several microns. After intravenous injection, it can significantly increase the medical ultrasound detection signal, and can improve the imaging effect of some organs and tissues that cannot be developed or poorly developed. . The emergence of ultrasound contrast agents makes up for the defects and insufficiencies of conventional ultrasound diagnosis, and can distinguish the different blood perfusion between normal tissue and diseased tissue, thus providing an important basis for the diagnosis ...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/223
Inventor 董飞宏张嘉宾王凯乐张珏方竞
Owner PEKING UNIV
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