Pharmaceutically acceptable salt, crystal form and preparation method of pyrazoloheteroaryl derivatives

Abstract

The invention relates to a pharmaceutically acceptable salt, crystal form and preparation method of pyrazolo heteroaryl derivatives. The new pharmaceutically acceptable salt and the new crystal form of the present invention have good stability and can be better used in clinical treatment.

Description

technical field [0001] The invention relates to a pharmaceutically acceptable salt, crystal form, preparation method and pharmaceutical application of pyrazoloheteroaryl derivatives. Background technique [0002] Toll-like receptors (toll-like receptors; TLRs) are an important class of protein molecules involved in innate immunity. TLRs are monomeric transmembrane non-catalytic receptors, usually expressed in sentinel cells such as macrophages and dendritic cells, which can recognize structurally conserved molecules produced by microorganisms. Once these microbes break through a physical barrier such as the skin or intestinal mucosa, they are recognized by TLRs, which in turn activate an immune cell response. (Mahla, RS. et al., Front Immunol. 4:248 (2013)). The ability of the immune system to widely recognize pathogenic microorganisms is partly due to the widespread existence of Toll-like immune receptors. [0003] There are at least 10 different TLRs in mammals. Ligand...

AI Technical Summary

Problems solved by technology

Generally speaking, amorphous pharmaceutical products have no regular crystal structure and often have other defects, such as poor product stability, fine crystallization, difficult filtration, easy agglomeration, poor fluidity, etc.

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