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Method for treating acute poisoning of canine paraquat

A technology of paraquat and hydroquinone, applied in the medical field, can solve problems such as complex ingredients, unsatisfactory drug safety, effectiveness and quality controllability, and no consideration of the inhibitory effect of excessive sodium azide

Pending Publication Date: 2019-11-22
THE FIRST AFFILIATED HOSPITAL OF HAINAN MEDICAL UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, on the one hand, due to the complexity and instability of the ingredients in the preparation, it cannot meet the requirements of drug safety, effectiveness and quality controllability; After quinone, inject paraquat solution into the solution, observe the reaction phenomenon, no solid is formed, and the concentration of paraquat and AHQDS has not decreased after 24h and 48h, indicating that hydroquinone alone is not enough to detoxify paraquat
However, in the "CN201610341330.6" invention, the inventor did not consider the inhibitory effect of excess sodium azide on the reaction between hydroquinone and paraquat

Method used

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  • Method for treating acute poisoning of canine paraquat
  • Method for treating acute poisoning of canine paraquat
  • Method for treating acute poisoning of canine paraquat

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Embodiment Construction

[0020] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0021] 1 Materials and methods

[0022] 1.1 Experimental materials

[0023]

[0024]

[0025] 1.2 Experimental equipment

[0026]

[0027] 1.3 Main experimental reagents

[0028] (1) Paraquat diluent: 10kg beagle dog, according to twice the explosive poisoning dose, 150mg / kg, a total of 1500mg paraquat, uniformly diluted to 10ml with 200g / L paraquat stock solution.

[0029] (2) "white plus black" suspension: 10kg beagle dog, mixed according to 800mg / kg activated carbon + 800mg / kg montmorillonite powder + 125ml mannitol.

[0030] (3) Antidote: 9,10-anthrahydroquinone-2,6-disulfonic acid was prepared int...

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Abstract

The invention discloses a method for treating acute poisoning of canine paraquat. The main component of a medicine used in the method is the hydroquinone compound or pharmaceutically-acceptable salt thereof, preferentially 9,10-anthrahydroquinone-2,6-disulfonic acid or 9,10-anthrahydroquinone-2,6-disulfonate (referred to as AHQDS). The application method includes the steps that according to the paraquat poisoning dosage in cooperation with different doses of detoxification medicines, treatment is conducted through a gavage mode. The medicine can obviously reduce the toxic reaction of canine paraquat, prevents the lung injuries caused by paraquat, and greatly increases the survival rate of paraquat acutely poisoned canines.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a method for treating acute paraquat poisoning in dogs. Background technique [0002] Paraquat, as a fast and non-selective quaternary ammonium salt herbicide, is widely used in agricultural cultivation because of its strong herbicidal effect and low price, which has contributed to the increase of food production, the reduction of production costs and the development of no-tillage technology around the world. It has made a huge contribution, and its economic benefits are immeasurable. It is precisely because of its wide application that various self-administration or mistaken consumption led to a large number of poisoning cases, which seriously threatened the life, health and safety of the Chinese people. Therefore, from July 1, 2014, the domestic production of paraquat water was stopped. In 2016 From July 1st, the domestic sales and use of paraquat water will be stopped, but t...

Claims

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Application Information

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IPC IPC(8): A61K31/194A61K31/19A61P39/02
CPCA61K31/194A61K31/19A61P39/02
Inventor 吕传柱刘笑然武春媛钱进吴东明李丽华黄琪锋
Owner THE FIRST AFFILIATED HOSPITAL OF HAINAN MEDICAL UNIV
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