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Hydrophilic antibacterial degradable ureter stent and preparing method thereof

A ureteral stent and hydrophilic technology, applied in the direction of catheters, coatings, etc., can solve the problems of cytotoxicity, increased active oxygen content, and poor biocompatibility of implants, and achieve the conditions of preventing protein adhesion and modification Mild, low biotoxic effect

Inactive Publication Date: 2019-11-19
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the continuous precipitation and accumulation of antibacterial metal ions or nanoparticles destroys the microenvironmental balance of the surrounding tissue, interferes with the normal growth of surrounding cells, promotes the increase of the content of reactive oxygen species (ROS) in the cells, produces cytotoxicity, and leads to implant failure. poor biocompatibility
[0009] It can be seen that the existing technical solutions cannot meet the various requirements of mechanical properties, antibacterial effect and biocompatibility of degradable stents

Method used

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  • Hydrophilic antibacterial degradable ureter stent and preparing method thereof

Examples

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Effect test

Embodiment 1

[0040] Such as figure 1 As shown, this embodiment provides a long-acting antibacterial and degradable ureteral stent tube, and its specific preparation steps are as follows:

[0041] Step 1: Put the ureteral stent tube made of PGLA (910) into deionized water for ultrasonic cleaning for 15 minutes, and put it into a laminar air flow cabinet to dry; set aside.

[0042] Step 2: Put 0.2g of dopamine hydrochloride and 0.12g of tris(hydroxymethyl)aminomethane (Tris-HCL) into 100mL of deionized water and mix evenly, and titrate the pH value to 8.5 with 0.01M NaOH and 0.01M HCL;

[0043] Step 3: Put the stent tube obtained in step 1 into the solution obtained in step 2, soak it in an aerobic environment at 37°C for 24 hours, take it out, ultrasonically clean it in deionized water for 20 minutes, and then dry it;

[0044]Step 4: dissolving the G3 polyamidoamine dendrimer in deionized water to form a 0.5wt% solution;

[0045] Step 5: Put the stent tube obtained in step 3 into the solu...

Embodiment 2

[0051] Such as figure 1 As shown, this embodiment provides a hydrophilic antibacterial and degradable ureteral stent tube, and its specific preparation steps are as follows:

[0052] Step 1: Put the ureteral stent tube made of PGA into deionized water for ultrasonic cleaning for 15 minutes, put it into the air laminar flow cabinet to dry; set aside.

[0053] Step 2: Put 0.2g of dopamine hydrochloride and 0.12g of tris(hydroxymethyl)aminomethane (Tris-HCL) into 100ml of deionized water and mix evenly, and titrate the pH value to 8.5 with 0.01M NaOH and 0.01M HCL;

[0054] Step 3: put the stent tube obtained in step 1 into the solution obtained in step 2, soak it in an aerobic environment at 37°C for 24 hours, take it out, clean it ultrasonically for 20 minutes, and then dry it;

[0055] Step 4: dissolving the G1 polyamidoamine dendrimer in deionized water to form a 3wt% solution;

[0056] Step 5: Put the stent tube obtained in step 3 into the solution obtained in step 4, take...

Embodiment 3

[0062] Such as figure 1 As shown, this embodiment provides a hydrophilic antibacterial and degradable ureteral stent tube, and its specific preparation steps are as follows:

[0063] Step 1: Put the ureteral stent tube made of PGLA (730) into deionized water for ultrasonic cleaning for 15 minutes, and put it into a laminar air flow cabinet to dry; set aside.

[0064] Step 2: Put 0.4g of dopamine hydrochloride and 0.12g of tris(hydroxymethyl)aminomethane (Tris-HCL) into 100ml of deionized water and mix evenly, and titrate the pH value to 8.5 with 0.01M NaOH and 0.01M HCL;

[0065] Step 3: put the stent tube obtained in step 1 into the solution obtained in step 2, soak it in an aerobic environment at 37°C for 24 hours, take it out, clean it ultrasonically for 20 minutes, and then dry it;

[0066] Step 4: dissolving the G5 polyamidoamine dendrimer in deionized water to form a 0.5wt% solution;

[0067] Step 5: Put the stent tube obtained in step 3 into the solution obtained in s...

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Abstract

The invention provides a hydrophilic antibacterial degradable ureter stent and a preparing method thereof. The surface of the ureter stent is provided with a hydrophilic antibacterial layer, the contact killing effect on bacteria is realized through the effect of polycations of amino-terminated dendrimer, and protein adhesion is prevented by forming a hydration layer. The preparing method includesthe steps of soaking the ureter stent prepared from a degradable material in a Tris-HCl buffer solution of dopamine hydrochloride so that the auto-polymerization of dopamine hydrochloride can happento the surface of the stent, then grafting polyamide-amine dendrimer, and conducting cleaning and drying to obtain the degradable ureter stent grafted with the hydrophilic antibacterial layer. The ureter stent is easy to prepare, the hydrophilic antibacterial layer has a lubricating effect after being reliably grafted on the surface of the stent, the releasing of an antibacterial agent and the toxicity caused by the releasing of the antibacterial agent do not exist, and the ureter stent has high biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of medical materials and medical devices, and in particular relates to a dendrimer-based highly hydrophilic antibacterial and degradable ureteral stent tube and a preparation method thereof. Background technique [0002] Ureteral stent has dual functions of internal drainage and internal stent. It is a common drainage tool in urology. It is mainly used for dilation treatment of renal ureteral stones, hydronephrosis, ureteral tumors, kidney transplantation and ureteral stricture. [0003] The indwelling time of ureteral stents is generally 2-6 weeks, and the existing clinical ureteral stents are all non-degradable polyurethane stents. After the implantation period, a second operation is required to remove the stent, which will damage the patient's urinary system. If the stent is placed for a long time, it will lead to more serious consequences, such as the loss of renal function, and even the need to remove t...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/08A61L29/14
CPCA61L29/06A61L29/085A61L29/14A61L29/148A61L2420/02C08L67/04C08L79/02
Inventor 王璐高立恒达骏王一惟徐明曦王忠邹婷王富军王李天牧
Owner DONGHUA UNIV
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