Application of callicarpa nudiflora extract in preparing hypoglycemic drug or health care product
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A kind of technology of nudibranchs and health products, which is applied in the direction of drug combination, medical preparations containing active ingredients, food science, etc., and can solve the problems that have not yet been seen.
Inactive Publication Date: 2019-11-19
深圳市南芮环保科技有限公司
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, there is no report about the e...
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0018] The preparation of embodiment 1 naked flower purple pearl extract
[0019] The extract of Aurora nudiflora is prepared by the following method: take 2 kg of natural air-dried leaves of Aurora nudiflora, crush them, add 4 L of water to boil for 1 hour, filter, add 3 L of water to the dregs of the medicine, continue to boil for 0.5 hour, filter, and combine the filtrates to obtain Total 1.5L of the water extract of Aurora nudiflora; put the water extract of Aurora nudiflora at room temperature, add 5.0L of 95% ethanol, put it in a refrigerator at 4°C overnight, centrifuge, remove protein and polysaccharide components, and supernatant Concentrate under reduced pressure, distill off ethanol to obtain a concentrated solution; freeze-dry the concentrated solution at -80°C to obtain the extract of Auranthus nudica.
Embodiment 2
[0020] Example 2 Study on the Hypoglycemic Effect of Radix Phytophthora Extract
[0021] 1. Materials
[0022] 1.1 Experimental animals
[0023] 60 healthy and clean SD rats, male, with a body weight of 180-220 g, were purchased from the Experimental Animal Research Center of Xinjiang Uygur Autonomous Region. New) 2011-0001.
[0024] 1.2 Drugs and reagents
[0025] Metformin hydrochloride tablets (Sino-American Shanghai Squibb Pharmaceutical Co., Ltd., batch number AAT0182); streptozotocin (STZ, Sigma company, batch number 101933545); citric acid (Tianjin Shengao Chemical Reagent Co., Ltd., batch number 20170224); Sodium (Shanghai Shanpu Chemical Co., Ltd., batch number 20160603); rat insulin ELISA kit (Jiangsu Jingmei Biotechnology Co., Ltd., batch number 20180306); TG, TC, LDL-C, HDL-C assay kits ( Nanjing Jiancheng Bioengineering Research Institute, batch numbers are 20180320, 20180322, 2180317, 20180316); high-sugar and high-fat feed composition (mass fraction): lard 1...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses application of a callicarpa nudiflora extract in preparing a hypoglycemic drug. The callicarpa nudiflora extract is prepared by adopting a water extraction and alcohol precipitation process. According to the application, it is verified that the callicarpa nudiflora extract can improve the mental state and fur luster of T2DM rats prepared by streptozotocin, improve the bodymass of the rats, reduce the FBG level and the area under a glucose tolerance curve, improve the glucose tolerance of the rats, significantly increase the HDL-C level of rat serum, reduce the levels of TG, TC and LDL-C, regulate the blood lipid metabolism of the rats, reduce the FINS level and HOMA-IR index of the rats, improve the insulin sensitivity of the rats, have a protective effect on boththe livers and pancreas islet tissues and stabilize the blood glucose of the rats by regulating the mRNA expression and protein expression of glucose-metabolism-related genes in livers and muscle tissues of the rats. The callicarpa nudiflora extract has a significant hypoglycemic effect, and can be applied to preparation of the hypoglycemic drug or health care product.
Description
technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to the application of the extract of Auranthus nudiflora in the preparation of hypoglycemic drugs or health care products. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. It is a chronic metabolic disease caused by defects in insulin secretion and / or its biological effects. In addition to the main feature of glucose metabolism disorders, it is also accompanied by severe lipid metabolism. abnormal. Type 2 diabetes is often accompanied by obesity and hyperlipidemia, which can easily induce multiple complications in the later stage, and can accumulate damage to multiple organs and systems, resulting in disability and high mortality. It is the main hazard to the life and health of diabetic patients. Therefore, it is extremely important to effectively prevent and control the occurrence and development of diabet...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more