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Application of callicarpa nudiflora extract in preparing hypoglycemic drug or health care product

A kind of technology of nudibranchs and health products, which is applied in the direction of drug combination, medical preparations containing active ingredients, food science, etc., and can solve the problems that have not yet been seen.

Inactive Publication Date: 2019-11-19
深圳市南芮环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the effect of Nadihuazizhu on lowering blood sugar.

Method used

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  • Application of callicarpa nudiflora extract in preparing hypoglycemic drug or health care product
  • Application of callicarpa nudiflora extract in preparing hypoglycemic drug or health care product
  • Application of callicarpa nudiflora extract in preparing hypoglycemic drug or health care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 naked flower purple pearl extract

[0019] The extract of Aurora nudiflora is prepared by the following method: take 2 kg of natural air-dried leaves of Aurora nudiflora, crush them, add 4 L of water to boil for 1 hour, filter, add 3 L of water to the dregs of the medicine, continue to boil for 0.5 hour, filter, and combine the filtrates to obtain Total 1.5L of the water extract of Aurora nudiflora; put the water extract of Aurora nudiflora at room temperature, add 5.0L of 95% ethanol, put it in a refrigerator at 4°C overnight, centrifuge, remove protein and polysaccharide components, and supernatant Concentrate under reduced pressure, distill off ethanol to obtain a concentrated solution; freeze-dry the concentrated solution at -80°C to obtain the extract of Auranthus nudica.

Embodiment 2

[0020] Example 2 Study on the Hypoglycemic Effect of Radix Phytophthora Extract

[0021] 1. Materials

[0022] 1.1 Experimental animals

[0023] 60 healthy and clean SD rats, male, with a body weight of 180-220 g, were purchased from the Experimental Animal Research Center of Xinjiang Uygur Autonomous Region. New) 2011-0001.

[0024] 1.2 Drugs and reagents

[0025] Metformin hydrochloride tablets (Sino-American Shanghai Squibb Pharmaceutical Co., Ltd., batch number AAT0182); streptozotocin (STZ, Sigma company, batch number 101933545); citric acid (Tianjin Shengao Chemical Reagent Co., Ltd., batch number 20170224); Sodium (Shanghai Shanpu Chemical Co., Ltd., batch number 20160603); rat insulin ELISA kit (Jiangsu Jingmei Biotechnology Co., Ltd., batch number 20180306); TG, TC, LDL-C, HDL-C assay kits ( Nanjing Jiancheng Bioengineering Research Institute, batch numbers are 20180320, 20180322, 2180317, 20180316); high-sugar and high-fat feed composition (mass fraction): lard 1...

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Abstract

The invention discloses application of a callicarpa nudiflora extract in preparing a hypoglycemic drug. The callicarpa nudiflora extract is prepared by adopting a water extraction and alcohol precipitation process. According to the application, it is verified that the callicarpa nudiflora extract can improve the mental state and fur luster of T2DM rats prepared by streptozotocin, improve the bodymass of the rats, reduce the FBG level and the area under a glucose tolerance curve, improve the glucose tolerance of the rats, significantly increase the HDL-C level of rat serum, reduce the levels of TG, TC and LDL-C, regulate the blood lipid metabolism of the rats, reduce the FINS level and HOMA-IR index of the rats, improve the insulin sensitivity of the rats, have a protective effect on boththe livers and pancreas islet tissues and stabilize the blood glucose of the rats by regulating the mRNA expression and protein expression of glucose-metabolism-related genes in livers and muscle tissues of the rats. The callicarpa nudiflora extract has a significant hypoglycemic effect, and can be applied to preparation of the hypoglycemic drug or health care product.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to the application of the extract of Auranthus nudiflora in the preparation of hypoglycemic drugs or health care products. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. It is a chronic metabolic disease caused by defects in insulin secretion and / or its biological effects. In addition to the main feature of glucose metabolism disorders, it is also accompanied by severe lipid metabolism. abnormal. Type 2 diabetes is often accompanied by obesity and hyperlipidemia, which can easily induce multiple complications in the later stage, and can accumulate damage to multiple organs and systems, resulting in disability and high mortality. It is the main hazard to the life and health of diabetic patients. Therefore, it is extremely important to effectively prevent and control the occurrence and development of diabet...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P3/10A23L33/105A61K127/00
CPCA61K36/85A61P3/10A23L33/105A61K2236/331A61K2236/39A61K2236/53A61K2236/51A23V2002/00
Inventor 陶琳马文玉易博
Owner 深圳市南芮环保科技有限公司
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