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Swelling-diminishing gel for plastic surgery and preparation method thereof

A technology of gel and gel matrix, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of poor gel permeability and slow onset of drug effects, and achieve Promote absorption, no toxic side effects, good disinfection effect

Inactive Publication Date: 2019-11-12
杭州中荷智慧城市科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this Chinese medicine gel for reducing swelling and relieving pain can reduce swelling and relieve pain, the permeability of the gel is poor, and the onset of drug effect is slow.

Method used

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  • Swelling-diminishing gel for plastic surgery and preparation method thereof
  • Swelling-diminishing gel for plastic surgery and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A detumescence gel for plastic surgery, comprising the following components in parts by weight: 15 g of turmeric extract, 200 g of gel base, 2 g of azone, 50 g of glycerin, and 6 g of polyglycerol methacrylate. The gel matrix is ​​carbomer gel with a mass fraction of 8%.

[0023] The extraction method of the turmeric extract is as follows: take 3kg of dry turmeric, pulverize it to obtain 70 mesh turmeric powder, under the conditions of extraction pressure 35Mpa, extraction temperature 60°C, extraction flow rate 50Hz, supercritical CO 2 Extract for 150min to obtain turmeric extract.

[0024] The preparation method of the above-mentioned detumescence gel for plastic surgery comprises the following steps:

[0025] (1) Carbomer is placed in water to swell for 18 hours to make a carbomer gel with a mass fraction of 8%;

[0026] (2) Add azone, glycerin, polyglycerol methacrylate, and stir for 15 minutes;

[0027] (3) Add turmeric extract and stir for 25 minutes to prepare....

Embodiment 2

[0029] A detumescence gel for plastic surgery, comprising the following components in parts by weight: 10 g of notopterygium extract, 150 g of gel matrix, 1 g of azone, 30 g of glycerin, and 5 g of polyglycerol methacrylate. The gel matrix is ​​carbomer gel with a mass fraction of 5%.

[0030] The extraction method of the notopterygium extract is as follows: dry and pulverize the notopterygium, pass through a 40-mesh sieve, add 4 times the weight fraction of 70% ethanol, place it in an ultrasonic-microwave extractor for extraction, control the ultrasonic power to 600W, and the microwave power Extract continuously at 600W for 2 hours, filter, and concentrate the filtrate under reduced pressure at 20°C to obtain a concentrate; extract the concentrate with ether, dry over anhydrous sodium sulfate, concentrate under reduced pressure at 45°C to remove the organic solvent, and obtain the notopterygium extract.

[0031] The preparation method of the above-mentioned detumescence gel f...

Embodiment 3

[0036] A detumescence gel for plastic surgery, comprising the following components in parts by weight: 20 g of jasmine extract, 220 g of gel matrix, 3 g of azone, 60 g of glycerin, and 8 g of polyglycerol methacrylate. The gel matrix is ​​sodium alginate gel with a mass fraction of 9%.

[0037] The extraction method of the jasmine extract is as follows: Weigh 2 kg of jasmine, crush it to obtain 70-mesh jasmine powder, and under the conditions of extraction pressure 45Mpa, extraction temperature 52°C, and extraction flow rate 50Hz, supercritical CO 2 Extracted for 160min to obtain the mountain gardenia extract.

[0038] The preparation method of the above-mentioned detumescence gel for plastic surgery comprises the following steps:

[0039] (1) Sodium alginate is placed in water to swell for 24 hours to make a sodium alginate gel with a mass fraction of 9%;

[0040] (2) Add azone, glycerin, polyglycerol methacrylate, and stir for 20 minutes;

[0041] (3) Add the extract of S...

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Abstract

The invention discloses a swelling-diminishing gel for plastic surgery and a preparation method thereof. The gel includes the following components in parts by weight: 10-20 parts of an active ingredient, 150-220 parts of a gel matrix, 1-3 parts of azone, 30-60 parts of glycerol, and 5-8 parts of PGMA. The swelling-diminishing gel has good disinfection and swelling-diminishing effects. The combineduse of azone and PGMA promotes the absorption of active ingredient by the human body. The active ingredient is prepared by natural plant extracts, which is environmentally friendly, has the dual effects of disinfection and sterilization, and has no toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of plastic surgery, and in particular relates to a detumescence gel for plastic surgery and a preparation method thereof. Background technique [0002] At present, with the development of the economy, people have higher and higher aesthetic requirements, and many people choose plastic surgery to make themselves beautiful. Plastic surgery generally adopts surgical methods, and the person undergoing plastic surgery has the risk of infection, which is usually resolved by smearing disinfectant. However, the disinfectant has a short action time and requires frequent disinfection measures, which is troublesome to use. The skin after surgical sutures often swells, which is a problem that disinfectants cannot solve. [0003] At present, the use of disinfection and swelling gel is a better choice. The gel has a long acting time and tight protection, but the delivery efficiency of the gel is not high. Improving the ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/06A61K47/14A61K47/22A61P29/00A61P31/02
CPCA61K9/0014A61K9/06A61K36/237A61K36/28A61K36/744A61K36/9066A61K47/14A61K47/22A61K2236/333A61K2236/37A61P29/00A61P31/02A61K2300/00
Inventor 吴敏
Owner 杭州中荷智慧城市科技有限公司
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