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Application of radish extract to preparation treating, preventing or improvement of Parkinson disease and preparation technology of radish extract

An extract and syndrome technology, applied in the application field of radish extract, can solve problems such as incurable, fluctuating symptoms, abnormal movement, and poor curative effect, and achieve the effects of environmental protection, rich sources, and improved moisture resistance

Inactive Publication Date: 2019-11-12
GUANGZHOU LIUSHUN BIO TEC CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current drug treatment cannot prevent the development of the disease, let alone cure it.
In particular, patients who take medication for a long time will develop tolerance to various Western medicines, and are prone to complications such as symptom fluctuations and abnormal movements, so that Western medicines are less effective in improving PD symptoms in the later stages of treatment.

Method used

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  • Application of radish extract to preparation treating, preventing or improvement of Parkinson disease and preparation technology of radish extract
  • Application of radish extract to preparation treating, preventing or improvement of Parkinson disease and preparation technology of radish extract
  • Application of radish extract to preparation treating, preventing or improvement of Parkinson disease and preparation technology of radish extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Present embodiment is the prescription and the technology of the tablet that every sheet contains 50% radish extract:

[0043] Table 1 Prescription Form for 1000 Tablets Containing Radish Extract

[0044]

[0045] The preparation technology of above-mentioned tablet, comprises the following steps:

[0046] 1. Put 250 grams of radish extract, 120 grams of mannitol, 97.5 grams of sorbitol, and 25 grams of hydroxypropyl methylcellulose in the above table into a multi-directional motion mixer and fully mix them uniformly to prepare the prepared mixed materials.

[0047] 2. Put the premixed material obtained above into a dry granulator, mix, convey, extrude, crush, and sieve through an 18-mesh screen to obtain dry granules.

[0048] 3. Add 7.5 grams of magnesium stearate to the dry granules prepared above to obtain a mixed powder. The mixed powder is placed in a multi-directional motion mixer for thorough mixing, and compressed with a rotary tablet press to obtain the p...

Embodiment 2

[0052] Present embodiment is the prescription and the technology of the hard capsule that every grain contains 50% radish extract:

[0053] Table 2 Prescription Form of 2000 Capsules Containing Radish Extract

[0054]

[0055]

[0056] The preparation technology of above-mentioned capsule, comprises the following steps:

[0057] 1. Place 300 grams of radish extract, 165 grams of silicified microcrystalline cellulose, and 120 grams of lactose in the above table in a multi-directional motion mixer, and fully mix them uniformly to obtain a premixed material.

[0058] 2. Add 6 grams of magnesium stearate and 9 grams of talcum powder to the above-mentioned premixed materials to obtain a mixed powder. The mixed powder is placed in a multi-directional motion mixer for full mixing and uniformity, and the obtained mixture is filled with a hard capsule automatic filling machine Capsules are obtained to obtain the capsules; finally, the prepared capsules are packaged.

Embodiment 3

[0060] Present embodiment is the prescription and the technology that every capsule contains the hard capsule of 75% radish extract:

[0061] Table 3 Prescription Form of 2000 Capsules Containing Radish Extract

[0062]

[0063] The preparation technology of above-mentioned hard capsule, comprises the following steps:

[0064] 1. Dissolve part of the povidone in the above table 3 in 160mL ethanol solution to make an alcohol solution, use it as an adhesive, and set aside.

[0065] 2. Put 300 grams of radish extract, 70 grams of microcrystalline cellulose, and the remaining povidone in the above table into a fluidized bed and mix well, add the alcohol solution of the above-mentioned binder at a certain flow rate, and fully boil Mixing, drying step granulation, and drying the resulting dry granules.

[0066] 3. Add 4 grams of magnesium stearate and 6 grams of talcum powder to the dry granules to obtain a mixed powder. The mixed powder is placed in a multi-directional motion ...

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Abstract

The invention discloses application of a radish extract to preparation treating, preventing or improvement of Parkinson disease and a preparation technology of the radish extract, and provides a medicine combination for preventing and treating Parkinson disease. The medicine combination comprises the radish extract; the radish extract is a mixture of an aqueous extract and an alcohol extract; andthe radish extract is extracted from one or more of a carmine radish, a white radish, a long feather crack radish, a red heart radix, a green peel and red heart radix, a big red tassel radix and oil radish seed. The invention further discloses a dosage form of medicine for preventing and treating Parkinson disease and a preparation method. The radish extract for preventing and treating Parkinson disease is natural in components and safe, the significant therapeutic effect is proved through animal experiment, the preparation method is convenient, and environmental protective, can be widely usedin preventing and treating of Parkinson disease, and provides a better choice for preventing and treating of Parkinson disease.

Description

technical field [0001] The invention relates to the application of a radish extract, in particular to the application of a radish extract in preventing and treating Parkinson's syndrome, and in particular to a medicine containing the radish extract and a preparation method thereof. Background technique [0002] Parkinson's disease (PD) is a neurodegenerative disease characterized by neurodegeneration of the nigrostriatal pathway, and it is also the second most common neurodegenerative disease after Alzheimer's disease. The main pathological features are the progressive degeneration and death of dopaminergic neurons in the midbrain and the formation of Lewy bodies in the cells, which eventually lead to the functional decline of the nigrostriatal dopaminergic system, resulting in movement disorders. The main clinical features are For prohibitive tremor, postural balance disorder, bradykinesia, muscle stiffness, often accompanied by cognitive impairment. Epidemiology shows tha...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P25/16
CPCA61K36/31A61K2236/331A61K2236/333A61P25/16
Inventor 刘兵戴静思董俊军钱学启王嫣李家杰陈能安邓联武
Owner GUANGZHOU LIUSHUN BIO TEC CO LTD
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