Endometriosis canceration related ovarian cancer diagnostic or prognostic marker and application

Abstract

The invention relates to an endometriosis canceration related ovarian cancer diagnostic or prognostic marker and application. Diagnosis and judgement of progression of disease of endometriosis canceration related ovarian cancer can be conducted according to the expression level of LncRNA BANCR of a body in eutopic endometrium. The LncRNA BANCR serves as the endometriosis canceration related ovarian cancer diagnostic or prognostic marker, and the LncRNA BANCR is applied to preparation of kits for diagnostic and / or prognostic assessment of endometriosis canceration related ovarian cancers. The LncRNA BANCR can serve as a novel biomarker for being used in diagnostic and / or prognostic assessment of the endometriosis canceration related ovarian cancers, and risk assessment of endometriosis canceration, and a chaff interferent corresponding to the LncRNA BANCR can serve as a novel drug, and has potential preventing and treating values to the endometriosis canceration related ovarian cancers.The endometriosis canceration related ovarian cancer diagnostic or prognostic marker can serve as the novel biomarker, and be applied to diagnostic and / or prognostic assessment of the endometriosis canceration related ovarian cancers, and has potential preventing and treating values to the endometriosis canceration related ovarian cancers.

Description

technical field [0001] The invention belongs to the field of medicine and biotechnology, and specifically relates to LncRNA BANCR as a marker and application of endometriosis malignant transformation-related ovarian cancer diagnosis or prognosis. Diagnosis and judgment of disease progression of ovarian cancer associated with malignant transformation of membranous dysplasia. Background technique [0002] Abnormal expression of long-chain non-coding is closely related to many diseases. BRAF-activated noncoding RNA (BRAF-activated noncoding RNA, BANCR) was first discovered in melanoma cells by Flockhart RJ et al. in 2012. It is a 693bp lncRNA located on chromosome 9. In order to clarify the role of the oncogene BRAF in the transcriptome of melanocytoma, this study conducted RNA sequencing on normal melanocytes with and without BRAFV600E expression and two types of melanocytes with BRAFV600E mutation, and found that BRAFV600E regulates 1 027 Protein-coding transcripts, 39 know...

AI Technical Summary

Problems solved by technology

Due to the malignant transformation of ectopic endometrium, the vigorously growing tumor tissue destroyed the original tissue of ectopic endometrium, coupled with the limitations of pathological materials, resulting in many missed diagnoses in the pathological diagnosis of malignant transformation of endometriosis, and the acquisition of malignant transformation tissue specimens and cell models of endometriosis Difficult, basic research is relatively lagging behind, so it is necessary to obtain new markers to help predict the risk of malignant transformation of endometriosis and diagnostic methods

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