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Medicine composition for treating skin melanoma and preparation method of medicine composition

A technology of melanoma, composition, applied in the field of medicine

Inactive Publication Date: 2019-11-05
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, nearly half of CMM patients are still in the advanced stage at the first diagnosis or enter into an advanced disease state due to recurrence and metastasis after surgery, and there is no chance of cure

Method used

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  • Medicine composition for treating skin melanoma and preparation method of medicine composition
  • Medicine composition for treating skin melanoma and preparation method of medicine composition
  • Medicine composition for treating skin melanoma and preparation method of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This embodiment provides an injection of a pharmaceutical composition for the treatment of skin melanoma. The operation is as follows: Weigh 500 mg of industrial hemp flower leaf extract and 500 mg of artesunate, add 200 mL of water for injection, and adjust the pH with 8% NaOH solution value to make it dissolve; add 3g of sodium chloride, add 0.2% activated carbon and boil for 15 minutes, filter, add water for injection to the filtrate to 1000mL; Sterilize by autoclaving at 110°C for 40 minutes.

Embodiment 2

[0026] This embodiment provides a drop pill of a pharmaceutical composition for the treatment of skin melanoma. The operation is as follows: Weigh 50 g of industrial hemp floral leaf extract, 10 g of artether, and additionally take an appropriate amount of polyethylene glycol 4000 and polyethylene glycol 6000 After heating and melting in a water bath at 80-85°C, add the above-mentioned two raw materials weighed, mix well, keep the temperature at 75°C, drop into liquid paraffin (0-5°C), and make 1000 capsules to obtain this product Invented drop pill dosage form.

[0027] In order to better illustrate the purpose and advantages of the present invention, the present invention describes the effect of the present invention as an antitumor agent through the following experimental examples, illustrating that the combined use of industrial hemp compounds and artemisinin compounds can effectively inhibit the growth of skin melanoma tumors . The doses of drugs used in the experimental...

experiment example 1

[0028] Experimental Example 1: The effect of combined application of cannabidiol and artemisinin on the growth of skin melanoma cells in nude mice

[0029] 1. Experimental materials

[0030] 1) Reagents: CBD (Sigma, St. Louis, MO, USA) was dissolved in ethanol, then prepared into a 1mg / ml solution with normal saline, and stored at 4°C; artemisinin (ART) and its derivative dihydroartemisinin (DHA) and artesunate (ARS) were purchased from McLean Biochemical Technology Co., Ltd., Shanghai, China, and 1% methylcellulose (purchased from Sigma-Aldrich Company, Shanghai, China) refrigerated at 4 °C, respectively. The solution is dissolved and prepared into a corresponding solution, which is prepared and used immediately.

[0031] 2) Cells: B16 melanoma cells

[0032] 3) Male nude mice, 4-5 weeks old

[0033] 2. Experimental grouping

[0034] 1) Control group: Nude mice were treated with an equal volume of drug solution

[0035] 2) CBD treatment group: CBD 50mg / kg, intraperitonea...

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Abstract

The invention provides a medicine composition effective in treating skin melanoma. The medicine composition contains first active components namely industrial cannabis compounds, second active components namely artemisinin compounds, and a preparation prepared from auxiliary materials which can be accepted by the first active components and the second active components pharmaceutically. The industrial cannabis compounds and the artemisinin compounds can be applied in a combined manner to be used for preparing an antitumor medicine. The medicine composition disclosed by the invention is large in safe dosage range and good in curative effects, and has good application prospects in treating the skin melanoma. The patent describes the composition and a preparation method thereof, and belongs to the field of medicine preparing.

Description

technical field [0001] The invention relates to a combined drug containing industrial hemp compounds and artemisinin compounds. The combined drug can be used to prepare antitumor drugs, especially drugs for treating skin melanoma. It belongs to the field of medical technology. Background technique [0002] Cancer is a disease of uncontrolled cell proliferation with complex causes involving multiple abnormalities at the genetic, epigenetic, cellular and tissue levels. High variability at the genome and epigenome levels, extreme heterogeneity at multiple biological levels from transcripts to proteins, and strong adaptability to the environment are the fundamental reasons why tumors have become the most difficult and difficult diseases to diagnose and treat. [0003] Cutaneous malignant melanoma (CMM) is a highly malignant tumor originating from skin melanocytes. Because melanocytes originate from the neural crest of the embryo, it can occur in the skin, eyeballs, digestive tr...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/366A61P35/00
CPCA61K31/05A61K31/366A61P35/00A61K2300/00
Inventor 栾云鹏郑双庆李志朋李襄
Owner 栾云鹏
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