Application of CUL7 in glioma diagnosis, treatment and prognosis
A technology for glioma and glioma cells, which is applied in the fields of biomedicine and molecular biology, and can solve problems such as unclear roles
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0057] 1. Materials and methods
[0058] 1.1 Cox proportional hazards model and TCGA database analysis
[0059] Cox proportional hazards models were used to select genes associated with patient survival and build a predictive model for future predictions. Time to outcome was defined as overall survival in months and disease-free survival in months. Select N genes to build a Cox regression model; for each gene Gj (j=1, 2, ..., N), the following Cox model is established for the risk of life status or death at time t.
[0060]
[0061] in is the baseline risk function of gene Gj, and X1, X2, ..., XP are covariates. Adjusted covariates included race, age, sex, KPM (Karnofsky performance) score, tumor status, and history of neoadjuvant tumors. The transcript abundance of glial-associated CUL7 was mined from The Cancer Genome Atlas (TCGA, http: / / cancergenome.nih.gov). In all, 702 glioma cases including low-grade glioma (LGG, n=529) and glioblastoma (GBM, n=173) from the TCG...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com