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Eye bonding sealant glue and preparation method thereof

A sealing glue, eye-use technology, applied in the field of medical materials, can solve the problem of secondary corneal injury, etc., and achieve the effects of strong adhesion, less astigmatism, and uniform tension

Active Publication Date: 2019-10-29
JIANGSU DISSUETECH MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this technical solution uses staples instead of sutures to simplify the surgical process, it requires at least 8 staples to achieve a good healing effect, and the staples themselves are not degradable and need to be taken out. Healed cornea causes secondary damage

Method used

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  • Eye bonding sealant glue and preparation method thereof
  • Eye bonding sealant glue and preparation method thereof
  • Eye bonding sealant glue and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, ophthalmic adhesive sealant complete set of raw materials

[0049] The complete set of raw materials for ophthalmic adhesive sealant of this embodiment is composed of a first component and a second component, the first component is an aldylated hyaluronic acid, and the second component is an aminated hyaluronic acid; The ring opening rate of hyaluronic acid is 60-80%, and the grafting rate of hyaluronic acid is 20-40%. Note: In the preparation method of each component, the ring-opening rate of aldylated hyaluronic acid can be controlled to 60-80%, and the grafting rate of aminated hyaluronic acid can be controlled by controlling the feeding ratio and reaction time. 20-40%.

[0050] The first component of this embodiment is made by following method:

[0051] A1. Dissolve hyaluronic acid in purified water to form a 5-100 mg / mL hyaluronic acid solution (in this embodiment: magnetic stirring is used to dissolve overnight). Sodium periodate is dissolved in p...

Embodiment 2

[0070] Embodiment 2, ophthalmic adhesive sealant

[0071] The ophthalmic adhesive sealant of this embodiment is prepared from the complete set of raw materials of the ophthalmic adhesive sealant in Example 1 through the following steps:

[0072] C1. Dissolve the first component in normal saline to form a first solution of 5-20 mg / mL, and dissolve the second component in normal saline to form a second solution of 5-20 mg / mL; in the first solution The concentration of the first component is the same as the concentration of the second component in the second solution.

[0073] Note: In actual use, after step C1, pass each solution through a 0.22μm filter head to sterilize, and then fill them in 5mL pre-filled glass syringes under a sterile environment for use.

[0074] C2. Blend the first solution and the second solution at a volume ratio of 1:1; when blending, use two syringes to communicate with the connectors and then push each other back and forth for 15-30s to mix evenly; i...

Embodiment 3

[0080] Embodiment 3, cytotoxicity detection experiment

[0081] This embodiment is used to detect the cytotoxicity of the gel obtained in Example 2 of Example 2.

[0082] 1. Preparation:

[0083] Blank control solution: DMEM medium containing 10% fetal bovine serum.

[0084] Positive control: 1% zinc diethyldithiocarbamate.

[0085] Negative control: high-density polyethylene, the extraction ratio is every 3cm 2 Add 1mL of leaching solution to high-density polyethylene, and extract for 72h.

[0086] Sample: the gel obtained in Example 2 of Example 2, the extraction ratio is to add 1mL extract for every 0.2g of gel, and extract for 72h. The obtained extract is used as a 100% extraction sample, and then diluted with the extract Samples were leached for 75%, 50%, 25%.

[0087] The solutions or extracts in all groups were all used in DMEM medium containing 10% fetal bovine serum.

[0088] 2. Experimental operation:

[0089] Mouse fibroblast L929 cells were used at 1×10 5 T...

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Abstract

The invention relates to eye bonding sealant glue and a preparation method thereof. Hydrogel is prepared from a first solution and a second solution, the first solution contains a first component which is formylation hyaluronic acid, and the second solution contains a second component which is amination hyaluronic acid. The preparation method comprises the step that the first solution and the second solution are mixed. The hydrogel can be used for sealant bonding treatment after eye operation treatment, for example, suture of penetrating keratoplasty or sealant of cornea trauma, repairing of retina with eye ground frozen or laser treatment and the like. Compared with a suture line, according to the eye bonding sealant glue, the needed operation time is shorter, the skill requirements of doctors are lower, the wound tension is more uniform, and astigmatism is not prone to occurring; and in addition, the anchoring strength of the hydrogel is high, and the implementation effect is good.

Description

technical field [0001] The invention relates to an ophthalmic adhesive sealant and a preparation method thereof, belonging to the technical field of medical materials. Background technique [0002] As far as the applicant knows, according to different indications, keratoplasty is divided into penetrating keratoplasty and lamellar keratoplasty. Penetrating keratoplasty is a surgical method in which a full-thickness transparent cornea is replaced by a full-thickness opaque cornea, and lamellar keratoplasty is a partial-thickness corneal transplantation method. Regardless of the corneal transplantation method, the cornea is fixed clinically with surgical sutures. There are two types of sutures: intermittent sutures and continuous sutures. Interrupted sutures are easy to adjust the sutures to reduce astigmatism after surgery, but the suture time is longer and the wound may not be tightly closed; continuous suture is less irritating, the wound is tightly closed, and the operatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08
CPCA61L24/08A61L2400/06C08L5/08
Inventor 曹彬吴亮亮万文倩朱健
Owner JIANGSU DISSUETECH MEDICAL TECH CO LTD
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