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Pharmaceutical preparation for preventing and/or treating nonalcoholic fatty liver disease

A pharmaceutical preparation and a technology for fatty liver disease, applied to the application of patchouli oil in the preparation of medicines for preventing and treating non-alcoholic fatty liver disease, the field of pharmaceutical preparations for preventing and/or treating non-alcoholic fatty liver disease, and achieving repairing pathological changes, inhibiting Hepatocyte steatosis, the effect of promoting industry

Inactive Publication Date: 2019-10-25
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report disclosing that patchouli oil has the effect of preventing and treating NAFLD and its application in the prevention and treatment of NAFLD

Method used

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  • Pharmaceutical preparation for preventing and/or treating nonalcoholic fatty liver disease
  • Pharmaceutical preparation for preventing and/or treating nonalcoholic fatty liver disease
  • Pharmaceutical preparation for preventing and/or treating nonalcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The present embodiment is the formula and preparation process of each tablet containing 10mg patchouli oil of the present invention, and described formula is as shown in table 1:

[0042] Table 1 Formulation of 10000 tablets containing patchouli oil

[0043]

[0044] The preparation technology of above-mentioned tablet, comprises the following steps:

[0045] Take patchouli oil, lactose, and starch in the above-mentioned prescription amount, mix uniformly, use starch slurry as a binder to carry out wet granulation, then dry, add magnesium stearate, mix uniformly, press into tablets, and obtain the patchouli oil Tablets, a total of 10,000 tablets are compressed, each tablet has a net weight of 138mg, and each tablet contains 10mg of patchouli oil.

[0046] Dosage: oral administration; the above tablets are used for the treatment of non-alcoholic fatty liver disease, corresponding symptoms: mild fatigue, loss of appetite, abdominal distension, belching, fullness in th...

Embodiment 2

[0048]The present embodiment is the formula and preparation process of each tablet containing 20mg patchouli oil of the present invention, and described formula is as shown in table 2:

[0049] Table 2 Formulation of 10000 tablets containing patchouli oil

[0050]

[0051] The preparation technology of above-mentioned tablet, comprises the following steps:

[0052] Get the patchouli oil, mannitol, and starch of the above-mentioned prescription amount, mix evenly, use hydroxypropyl methylcellulose as a binder to carry out wet granulation, then dry, add magnesium stearate, mix evenly, and press into tablets. Obtain the patchouli oil tablet, compress 10000 tablets altogether, each tablet has a net weight of 148 mg, and each tablet contains 20 mg of patchouli oil.

[0053] Dosage: oral administration; the above tablets are used for the treatment of non-alcoholic fatty liver disease, corresponding symptoms: mild fatigue, loss of appetite, abdominal distension, belching, fullnes...

Embodiment 3

[0055] The present embodiment is the formula and preparation process of each tablet containing 40mg patchouli oil of the present invention, and described formula is as shown in table 3:

[0056] Table 3 Formulation of 10000 tablets containing patchouli oil

[0057]

[0058]

[0059] The preparation technology of above-mentioned tablet, comprises the following steps:

[0060] Take patchouli oil, sorbitol, and starch in the above-mentioned prescription amount, mix uniformly, use starch slurry as a binder to carry out wet granulation, then dry, add sodium lauryl sulfate, mix uniformly, press into tablets, and obtain the described Patchouli oil tablets, compressed 10,000 tablets in total, each tablet has a net weight of 168mg, and each tablet contains 40mg of patchouli oil.

[0061] Dosage: oral administration; the above tablets are used for the treatment of non-alcoholic fatty liver disease, corresponding symptoms: mild fatigue, loss of appetite, abdominal distension, belc...

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Abstract

The invention belongs to the field of biomedicine, and relates to a pharmaceutical preparation for preventing and / or treating nonalcoholic fatty liver disease and an application of patchouli oil in preparing a medicament for preventing and treating nonalcoholic fatty liver disease. The active ingredient of the pharmaceutical preparation comprises patchouli oil, wherein the patchouli oil accounts for 0.71 to 40 percent of the weight of the pharmaceutical preparation. The patchouli oil is applied to drugs for preventing or treating nonalcoholic fatty liver disease, so that nonalcoholic fatty liver disease can be effectively prevented and / or treated, new application of patchouli oil is increased, and industry and commercialization of patchouli oil are promoted.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a pharmaceutical preparation for preventing and / or treating nonalcoholic fatty liver disease and the application of patchouli oil in the preparation of medicines for preventing and treating nonalcoholic fatty liver disease. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, with a prevalence as high as 20% to 30% in the general population worldwide, and more than half of the people worldwide have NAFLD Danger. NAFLD refers to a clinicopathological syndrome characterized by hepatic steatosis without a history of excessive alcohol and other definite liver injury factors, including simple fatty liver, nonalcoholic steatohepatitis and its related liver fibrosis, Cirrhosis and hepatocellular carcinoma. At the same time, as a component of metabolic syndrome, NAFLD is related to various pathogenic factors such as obes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61P1/16A61K127/00
CPCA61K36/532A61P1/16
Inventor 刘煜洪苏子仁陈建南黎玉翠徐楠吴雪
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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