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Application of 1-deoxynojirimycin in treatment of diabetic cardiomyopathy and liver injury

A technology for deoxynojirimycin and diabetic cardiomyopathy, which is applied in the field of medicine, can solve the problems that there is no diabetic myocardial damage, special treatment drugs for reversing diabetic myocardial damage, etc. Effects of Cardiovascular Endothelial Cell Proliferation

Pending Publication Date: 2019-10-25
陕西含光生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no special therapeutic drug that can effectively improve diabetic myocardial injury and reverse the development of diabetic myocardial injury

Method used

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  • Application of 1-deoxynojirimycin in treatment of diabetic cardiomyopathy and liver injury
  • Application of 1-deoxynojirimycin in treatment of diabetic cardiomyopathy and liver injury
  • Application of 1-deoxynojirimycin in treatment of diabetic cardiomyopathy and liver injury

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Embodiment Construction

[0022] In order to facilitate a further understanding of the present invention, the examples provided below illustrate it in more detail. However, these examples are only for a better understanding of the invention and are not used to limit the scope or implementation principle of the invention, and the embodiments of the invention are not limited to the following content.

[0023] 1. Materials and methods

[0024] 1.1 Animals

[0025] Male C57BL / 6 mice, weighing 20-25 g, 8 weeks old, were provided by the Experimental Animal Center of Air Force Military Medical University.

[0026] 1.2 Reagent

[0027] Mulberry leaf extract (ML) was purchased from Xi'an Ruibo Biotechnology Co., Ltd., ingredient specification 1-DNJ5%, mulberry leaf flavonoids 10%; rutin (Rutin) was purchased from Solarbio company, purity ≥ 95%; quercetin (Quercetin ) was purchased from Solarbio, with a purity of ≥95%; 1-deoxynojirimycin (1-DNJ) was purchased from Yuanye Biology, with a purity of ≥98%; Acarbo...

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Abstract

The invention relates to application of 1-deoxynojirimycin in the treatment of diabetic cardiomyopathy and liver injury. 1-Deoxynojirimycin is a known potent alpha-glucosidase inhibitor. The applicable field of 1-deoxynojirimycin is widened herein; the use of 1-deoxynojirimycin or its pharmaceutically acceptable salts in the treatment and / or prevention of diabetic cardiomyopathy and liver injury is provided for the first time; experiments show that 1-deoxynojirimycin plays a positive role in myocardial protection aspects, such as lowering cardiac oxidative stress level of a diabetic patient, inhibiting cardiovascular endothelial cell proliferation of the diabetic patient, and inhibiting myocardial fiber proliferation of the diabetic patient; it is expected to develop 1-deoxynojirimycin into drugs to treat diabetic cardiomyopathy, thereby filling the blank of the prior art.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of 1-deoxynojirimycin in the treatment of diabetic cardiomyopathy and liver injury. Background technique [0002] Diabetic Cardiomyopathy (DCM for short) is a myocardial disease that cannot be explained by hypertensive heart disease, coronary atherosclerotic heart disease and other heart diseases. It was officially named by Rubler in 1972. of. The etiology of DCM mainly includes myocardial cell metabolic disorder, myocardial cell calcium transport defect, coronary microvascular disease, myocardial interstitial fibrosis, cardiac autonomic neuropathy, etc., and the clinical manifestations are heart failure, arrhythmia, angina pectoris, cardiogenic shock, etc. . At present, there is no specific therapeutic drug that can effectively improve diabetic myocardial injury and reverse the development of diabetic myocardial injury. The invention provides a method for t...

Claims

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Application Information

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IPC IPC(8): A61K31/445A61K31/352A61K31/7048A61K36/605A61P9/00A61P3/10A61P1/16A61P13/12
CPCA61K31/445A61K31/352A61K31/7048A61K36/605A61P9/00A61P3/10A61P1/16A61P13/12
Inventor 王四旺曹宇李瑶王静
Owner 陕西含光生物科技有限公司
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