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Two flavonoid compounds in purslane as well as extraction and separation method and application of two flavonoid compounds

A flavonoid compound and separation method technology, which is applied in the field of flavonoid compound and its extraction and separation, can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2019-10-08
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Two flavonoid compounds in purslane as well as extraction and separation method and application of two flavonoid compounds
  • Two flavonoid compounds in purslane as well as extraction and separation method and application of two flavonoid compounds
  • Two flavonoid compounds in purslane as well as extraction and separation method and application of two flavonoid compounds

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Embodiment Construction

[0026] The present invention will be described in detail below in conjunction with specific implementation.

[0027] The present invention provides two new compounds, the molecular formula is C 18 h 16 o 5 、C 18 h 18 o 5 , respectively named 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one and 3-(2-hydroxybenzyl)-6,8-dimethoxychroman-4-one, the chemical structural formulas are:

[0028]

[0029] The two new compounds are respectively named 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one and 3-(2-hydroxybenzyl)-6,8-dimethoxychroman-4-one according to their structures , Tables 1 and 2 are the NMR data of the two flavonoids: 1 H-NMR with 13 C-NMR in CCl 3 D.

[0030] Table 1 NMR data of the new compound 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one of the present invention

[0031] serial number δ C

Types of δ H (J in Hz)

1 O 2 151.11 CH 7.87，s 3 125.51 C 4 178.73 C 5 92.58 CH 6.42，d，(2.2) ...

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Abstract

The invention relates to the fields of extraction and separation of Chinese traditional medicines and in particular relates to two novel flavonoid compounds extracted, separated and identified from purslane as well as an extraction and separation method of the two flavonoid compounds. Molecular formulae of the two novel flavonoid compounds are respectively C18H16O5 named 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one and C18H18O5 named 3-(2-hydroxybenzyl)-6,8-dimethoxychroman-4-one. The invention further provides the extraction and separation method of the novel compounds, and separation,purification and preparation are performed by sequentially adopting decoction extraction, silica column chromatography, polyamide column chromatography, ODS medium-pressure column purification, Sephadex LH-20 and recrystallization. The novel compounds adopt the structures of HR-ESI-TOF-MS, 1H-NMR and 13C-NMR and are authenticated as two novel flavonoid compounds by adopting a two-dimensional nuclear magnetism spectrum method. The novel flavonoid compounds have potential anti-inflammatory, anti-tumor and anti-oxidation activities, and the novel flavonoid compounds and salts or derivatives thereof can be used as primers for synthesizing other compounds and raw materials for novel drug development and pharmacological activity research to prepare anti-inflammatory, anti-tumor and anti-oxidation drugs or health care products.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to flavonoids extracted, separated and identified from purslane medicinal materials and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade tolerant, widely distributed and rich in resources, and has attracted much attention as a wild plant with dual uses for medicine and food. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat and detoxification, cooling blood and stopping bleeding, and stopping dysentery. Insect bites, blood in the stool, hemorrhoids, metrorrhagia, etc. [0003] Modern pharmacological stud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/22A61P29/00A61P35/00A61P39/06A23L33/105
CPCC07D311/22A61P29/00A61P35/00A61P39/06A23L33/105A23V2002/00A23V2200/30A23V2200/308A23V2250/2116
Inventor 英锡相段阳张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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