Sulfonate functionalized covalent organic polymer solid-phase extraction column

Abstract

The invention discloses a solid-phase extraction column which has a sulfonate functionalized covalent organic polymer (COPTPBA-BPDA@SA) as a filler, and a preparation method and application of the solid-phase extraction column. The preparation method of the solid-phase extraction column comprises the following steps: firstly, preparing a matrix covalent organic polymer (COPTPBA-BPDA) from 1,3,5-tri(4-ammonia phenyl) benzene (TPBA) and 4-biphenyldicarboxaldehyde (BPDA) as reaction raw materials; further enabling COPTPBA-BPDA to react with sulfanilic acid so as to obtain COPTPBA-BPDA@SA; and putting the COPTPBA-BPDA@SA into a stainless steel hollow column tube, so as to obtain the solid-phase extraction column. As the solid-phase extraction column filled with the COPTPBA-BPDA@SA is adopted as an extraction medium, an on-line solid-phase (micro) extraction-high performance liquid chromatography combined system is established, and thus enrichment extraction and purification on a nonpolar or weak-polarity analysis target or a positive ionized analysis target can be achieved. The solid-phase extraction column is simple in process, simple and convenient to operate, easy to popularize, wide in applicable analysis target and wide in application prospect.

Description

technical field [0001] The invention belongs to the field of solid-phase extraction column preparation, in particular to a covalent organic polymer (COP) functionalized with sulfonate groups TPBA-BPDA @SA) for the preparation of packed solid-phase extraction columns. Background technique [0002] Covalent organic polymer (COP) is a new type of porous material composed of light elements, such as B, C, N, O, which is connected by covalent bonds. It has a variety of structures and can be mainly divided into boron , amines, triazines and others. Covalent organic polymer (COP) has a permanent pore structure, good physical and chemical stability and thermal stability, good adsorption capacity and other excellent properties, and has been widely used in the fields of gas storage, catalysis, photoelectricity, and adsorption. Attention has also been applied in the field of solid phase extraction. For example, Shuo Wang et al. (Liu J M, Hao J L, Wang S, et al. RSC Adv., 2018, 8, 268...

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