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Application of cortex magnoliae officinalis in preparing anti-influenza drugs

An anti-influenza drug, Magnolia officinalis technology, applied in antiviral agents, medical formulas, plant raw materials, etc., can solve the problems of H5N1 strong pathogenicity, high mortality, and no ready-made vaccines, so as to enhance the anti-influenza effect and inhibit copy effect

Inactive Publication Date: 2019-10-01
GUANGZHOU INST OF RESPIRATORY DISEASE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are the following problems in the prevention and treatment of influenza: 1. Due to the high variability of influenza virus, the vaccine can only partially control the outbreak of influenza. When a new influenza virus outbreak occurs, there is no ready-made vaccine available, and the development of new vaccines needs certain time [4]
2. Anti-influenza drugs such as M2 ion channel blockers amantadine and rimantadine, and neuraminidase inhibitors zanamivir and oseltamivir have limited clinical application due to severe drug resistance and side effects [5,6,7,8] 3. In recent years, there have been new cases of influenza A virus subtypes infecting people, which indicates that there may be a large influenza epidemic, such as highly pathogenic avian influenza H5N1, which has strong pathogenicity and high mortality after infection. bring panic [2,9]
In recent years, studies have shown that honokiol derivatives have the effect of inhibiting the activity of influenza virus neuraminidase [47,48] , but there is no report of honokiol and magnolol against influenza

Method used

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  • Application of cortex magnoliae officinalis in preparing anti-influenza drugs
  • Application of cortex magnoliae officinalis in preparing anti-influenza drugs
  • Application of cortex magnoliae officinalis in preparing anti-influenza drugs

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Embodiment Construction

[0074] The present invention will be further described below in conjunction with the accompanying drawings. It should be noted that this embodiment is based on the technical solution, and provides detailed implementation and specific operation process, but the protection scope of the present invention is not limited to the present invention. Example.

[0075]In this example, by establishing an anti-influenza drug screening method, it was found that HNK and MGN can effectively inhibit the replication of influenza virus from more than 500 plant extract monomers, and HNK has a higher inhibition efficiency, as shown in Table 1 and figure 2 shown. Moreover, the PR8 influenza virus used in this example is an amantadine-resistant virus strain. When HNK and MGN are used in combination with amantadine, the inhibitory effect is more significant.

[0076] Table 1 HNK and MGN inhibit influenza virus replication

[0077]

[0078] The experimental methods corresponding to Table 1 are ...

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Abstract

The invention discloses application of cortex magnoliae officinalis in preparing anti-influenza drugs. Through experiments, it is proved that active ingredients of the cortex magnoliae officinalis-traditional Chinese medicine monomer magnolol has the advantages that the magnolol can effectively inhibit influenza virus replication by specifically inhibiting the expression of influenza virus M2 ionchannel protein, and the synergistic enhancement with anti-influenza drugs oseltamivir, amantadine, rimantadine and ribavirin can enhance the anti-influenza effect of the antiviral drugs.

Description

technical field [0001] The invention relates to the technical field of anti-influenza drugs, in particular to the application of magnolia officinalis in preparing anti-influenza drugs. Background technique [0002] Influenza virus belongs to the Orthomyxoviridae family, is spherical or filamentous, and is a single-stranded segmented negative-strand RNA virus. According to the antigenicity of influenza virus nucleoprotein and matrix protein, influenza virus can be divided into A, B, C three types (or called A, B, C three types) [1] . Among them, type B and type C influenza mainly cause local epidemic and sporadic. The type A influenza virus is divided into several subtypes according to the antigenic differences of hemagglutinin (HA) and neuraminidase (Neuraminidase, NA). Rapid, variable antigens, strong infectivity and pathogenicity, fast transmission speed, can cause seasonal influenza and outbreaks of influenza pandemics, is an acute respiratory infectious virus that ser...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K31/05A61K31/215A61K31/13A61K31/7056A61P31/16
CPCA61K31/05A61K31/13A61K31/215A61K31/7056A61K36/575A61P31/16A61K2300/00
Inventor 陈凌李楚芳潘蔚绮
Owner GUANGZHOU INST OF RESPIRATORY DISEASE
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