Single-impulse panoramic photoacoustic computed tomography (sip-pact)

A technology of light pulses and photoacoustic signals, applied in calculation, diagnosis, echo tomography, etc., can solve problems such as inability to clearly distinguish sub-organ features, poor time resolution, etc.

Active Publication Date: 2019-09-27
UNIV OF WASHINGTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PACT has been able to image depths beyond 10 mm, but hardware and sensor design limitations make possible a trade-off between image resolution and temporal resolution / frame rate
PACT systems typically utilize data acquisition multiplexing to enhance image resolution but have poor temporal resolution due to multiplexing delays, or utilize ultrasound transducer arrays capable of higher frame rates but due to Partial acoustic detection coverage without clear resolution of sub-organ features

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0272] Example 1: 3D Whole Body PACT Using the SIP-PACT System

[0273] To demonstrate 3D whole-body photoacoustic computed tomography (PACT) imaging using the SIP-PACT system and method described herein, the following experiments were performed.

[0274] Adult 8-10 week-old nude mice (Hsd: Athymic Nude-FoxlNU, Harlan Co.; body weight 20-30g) were used for in vivo whole-body imaging experiments. Throughout the experiment, each mouse was maintained under anesthesia using 1.5% vaporized isoflurane. For brain imaging, mice were secured to a laboratory-made imaging platform (see Figure 25 ), and the cortical surface is positioned to align with the focal plane of the annular transducer array. During whole-body imaging experiments, the front and rear legs of the mice were strapped to the top and bottom of a laboratory-made holder, respectively, to keep the mice upright during imaging. The top of the holder consisted of an aluminum tube attached to the mouse's nose and mouth, and...

Embodiment 2

[0278] Example 2: 2D Time-Resolved Imaging of Cardiac and Respiratory Cycles Using the SIP-PACT System

[0279] To demonstrate 2D time-resolved whole-body imaging of cardiac and respiratory cycles using the SIP-PACT system and method described herein, the following experiments were performed.

[0280] Nude mice were prepared and mounted on Figure 1B shown in the SIP-PACT system. The mouse is positioned in the SIP-PACT system such that the focal plane of the annular transducer array passes through the heart of the mouse, producing the same Figure 2B The PA image shown in is similar to the PA image. The operation of the SIP-PACT system is similar to that in Example 1, using full-circular side illumination and side detection, and emitting 1064 nm laser pulses at a repetition rate of 50 Hz to the same cross-section of the mouse thorax to obtain time-series images.

[0281] Figure 3A are representative images of transverse sections through the mouse thoracic cavity. At an i...

Embodiment 3

[0286] Example 3: Functional Imaging Using the SIP-PACT System

[0287] To demonstrate functional imaging using the SIP-PACT system and methods described herein, the following experiments were performed.

[0288] In vivo brain function and CTC imaging were performed using adult 3-4 month old Swiss Webster mice (Hsd:ND4, Swiss Webster, Harlan Co.; body weight 20-30 g). Hair was removed from each mouse with a clipper and depilatory cream before functional brain imaging using the SIP-PACT system. Each mouse was then mounted on a laboratory-fabricated imaging platform and the cortical surface of the brain was aligned with the focal plane of the transducer array as described in Example 1. Each mouse breathed inhaled gas with different oxygen concentrations to systematically adjust the oxygen saturation (sO) of hemoglobin in mice during SIP-PACT functional imaging. 2 ), as described in detail below.

[0289] Using a SIP-PACT system similar to the system described in Example 1 (se...

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Abstract

A single-impulse panoramic photoacoustic computed tomography (SIP-PACT) system for small-animal whole-body imaging is disclosed. In addition, a dual-speed of sound image universal back-projection reconstruction method is disclosed. Further, a PACT system for imaging a breast of a subject is disclosed.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 427470, filed November 29, 2016, which is hereby incorporated in its entirety. [0003] Statement on Federal Government Research Funding [0004] This invention was made with United States Government support and was awarded Grant No. EBO16963 by the National Institutes of Health. The US Government has certain rights in this invention. technical field [0005] The present invention generally relates to photoacoustic tomography systems for capturing whole-body images of small animals at high frame rates and high resolution. Background technique [0006] Small animals, especially rodents, are essential models for preclinical research, and they play an important role in simulating human physiology and development, guiding research on human diseases, and advancing the search for effective treatments. The ability to directly visualize the dynamics in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N29/06A61B8/13
CPCA61B5/0095G01N29/06G01N29/0672G01N29/2418G01N21/1702G01N2291/02475G01N21/4795A61B5/721A61B5/024A61B5/113A61B2562/0247A61B5/4312A61B5/318A61B5/0091G06T11/006G06T2211/421
Inventor 汪立宏李磊朱立仁马诚
Owner UNIV OF WASHINGTON
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