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Low-viscosity hollow capsule release agent and preparation method thereof

A hollow capsule and mold release agent technology, which is applied in the field of capsule mold release, can solve problems such as large water demand, and achieve the effects of reducing cost input, reducing viscosity and friction coefficient, and being easy to wash.

Inactive Publication Date: 2019-09-27
JIANGSU LEFAN CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the viscosity of the release agent is low, the active ingredients are still mainly oil, so the water needs a lot after the preparation is completed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A low-viscosity hollow capsule release agent, comprising the following components in parts by weight: 500 parts of purified water, 1 part of sodium lauryl sulfate, 35 parts of pullulan, 80 parts of liquid paraffin, Dendrobium officinale 5 parts of extract, 1 part of castor oil.

[0021] The preparation method of the hollow capsule release agent of above-mentioned low viscosity, comprises the following steps:

[0022] Step 1, mix liquid paraffin and castor oil, pour into a reaction kettle, stir and mix, heat to 85°C at a speed of 10°C / min, and keep warm for 10 minutes to obtain mixture A;

[0023] Step 2, mix the extract of pullulan polysaccharide and Dendrobium candidum, put it into the reaction kettle, and heat it to 30°C at 1°C / min to obtain the mixture B;

[0024] Step 3, when mixture A cools down to 30°C, add mixture B, then add sodium lauryl sulfate and purified water, after emulsification reaction, filter to obtain a release agent with a viscosity of 38mPas and a...

Embodiment 2

[0027] A low-viscosity hollow capsule release agent, comprising the following components in parts by weight: 508 parts of purified water, 1 part of sodium lauryl sulfate, 38 parts of pullulan, 85 parts of liquid paraffin, Dendrobium officinale 8 parts of extract, 1 part of castor oil.

[0028] The preparation method of the hollow capsule release agent of above-mentioned low viscosity, comprises the following steps:

[0029] Step 1, mix liquid paraffin and castor oil, pour into a reaction kettle, stir and mix, heat to 88°C at a speed of 12°C / min, and keep warm for 22 minutes to obtain mixture A;

[0030] Step 2, mix the extract of pullulan polysaccharide and Dendrobium candidum, put it into the reaction kettle, and heat it to 30-45°C at a speed of 2°C / min to obtain the mixture B;

[0031] Step 3, when mixture A cools down to 30-40°C, add mixture B, then add sodium lauryl sulfate and purified water, after emulsification reaction, filter to obtain a dehydration product with a vi...

Embodiment 3

[0034] A low-viscosity hollow capsule release agent, comprising the following components in parts by weight: 510 parts of purified water, 2 parts of sodium lauryl sulfate, 40 parts of pullulan, 86 parts of liquid paraffin, Dendrobium officinale 12 parts of extract, 3 parts of castor oil.

[0035] The preparation method of the hollow capsule release agent of above-mentioned low viscosity, comprises the following steps:

[0036] Step 1, mix liquid paraffin and castor oil, pour into a reaction kettle, stir and mix, heat to 90°C at a speed of 15°C / min, and keep warm for 25 minutes to obtain mixture A;

[0037] Step 2, mix the extract of pullulan and Dendrobium candidum, put it into the reaction kettle, and heat it to 45°C at a speed of 3°C / min to obtain mixture B;

[0038] Step 3, when mixture A cools down to 40°C, add mixture B, then add sodium lauryl sulfate and purified water, after emulsification reaction, filter to obtain a release agent with a viscosity of 50mPas and a coef...

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Abstract

The invention discloses a low-viscosity hollow capsule release agent and a preparation method thereof. The release agent comprises the following components of, in parts by weight, 500-510 parts of purified water, 1-2 parts of lauryl sodium sulfate, 35-40 parts of pulullan, 80-86 parts of liquid paraffin, 5-12 parts of dendrobium officinale leach liquor and 1-3 part of castor oil; the liquid paraffin and the castor oil are mixed, the mixture is poured into a reaction kettle, after stirring and mixing are conducted, and the temperature is heated to 85-90 DEG C, after heat preservation is conducted for 10-25 minutes, a mixture A is obtained; the pullulan and the dendrobium officinale extracting solution are mixed, the mixture is put into a reaction kettle, the temperature is heated to 30-45 DEG C, and a mixture B is obtained; and when the mixture A is cooled to 30-40 DEG C, the mixture B is added, then the lauryl sodium sulfate and the purified water are added, after emulsion reaction is carried out, and filtering is conducted to obtain the release agent. The release agent is simple in component and small in friction coefficient, a used mold is easy to wash, and the release agent has good application prospect.

Description

technical field [0001] The invention belongs to the technical field of capsule release, and in particular relates to a low-viscosity hollow capsule release agent and a preparation method thereof. Background technique [0002] Hollow capsules are a commonly used dosage form in the pharmaceutical industry. Due to the problem of material selection, the demoulding during the preparation process requires the help of a release agent to ensure that it will not be damaged. Existing mold release agents generally have disadvantages such as high viscosity, small oil film distribution surface, thick coating, and large usage. After gluing, the capsules are prone to lace, and the glue is unevenly distributed on the mold, resulting in large differences in capsule particle weight. , Filling volume is not easy to control and other consequences. Therefore, a release agent with low viscosity and small coefficient of static friction is needed to solve the existing problems. [0003] Applica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/60
CPCB29C33/60
Inventor 何中浩方忠明朱静朱文秀
Owner JIANGSU LEFAN CAPSULE
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