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Antibiotic combination containing Avibactam and application of antibiotic combination

A use and bacterial technology, applied in the field of compositions containing avibactam and carbapenem antibiotics, can solve the problems of drug resistance and non-inhibition of metallo-beta-lactamases, and achieve the improvement of bacterial drug resistance and toxicity Reduced effect

Pending Publication Date: 2019-09-24
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Journal of Third Military Medical University, 2013,35(23):2498-2501" pointed out that avibactam can inhibit group A (including ESBLs and KPC enzymes), group C (mainly AmpC enzyme) and part of group D Amidase (such as OXA-48), but usually can not inhibit the metallo-beta-lactamase of group B, the structure of avibactam is shown in formula I
Carbapenems are highly stable to ESBLs enzymes (Extended Spectrum Beta-Lactamases, extended-spectrum β-lactamases) of group A and AmpC enzymes of group C (AmpC β-lactamases), but can be inhibited by B Hydrolytic inactivation of group metallo-β-lactamases, resulting in resistance to carbapenem antibiotics

Method used

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  • Antibiotic combination containing Avibactam and application of antibiotic combination
  • Antibiotic combination containing Avibactam and application of antibiotic combination
  • Antibiotic combination containing Avibactam and application of antibiotic combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Bacteriostatic Test of Avibactam-Carbapenem Antibiotics in Vitro

[0033] 1. Experimental materials

[0034] The experimental strain was obtained from the clinical isolates of Huashan Hospital of Fudan University, and was confirmed as a carbapenemase-producing strain by existing technology (the confirmation method of carbapenemase production can refer to: Pasteran. Simplified Protocol for Carba NP Test for Enhanced Detection of Carbapenemase Producers Directly from Bacterial Cultures[J].Journal of Clinical Microbiology,2015,53(12):3908-3911; gene phenotype detection method for carbapenemase production can refer to: Cheng Kuo. imCIM detection of B-type carbapenemase Evaluation of the effect of mycoenase[J].Journal of Clinical Laboratory,2017,35(1):31-35;He Jianye.Analysis of resistance genes of carbapenem-resistant Enterobacteriaceae[J].Laboratory Medicine , 2017, 32(11):985-989). All other materials used in this experiment can be obtained commercially.

[0035] 2. Exp...

Embodiment 2

[0098] Avibactam-meropenem fractional inhibitory concentration index (fractional inhibitory concentration, FIC)

[0099] 1. Experimental materials

[0100] The experimental strains were obtained from the clinical isolates of Huashan Hospital of Fudan University, involving 2 genera and 2 strains, including 21 strains of Klebsiella pneumoniae (including 10 strains producing KPC-type carbapenemase and OXA-producing strains). 11 carbapenemase strains), 2 Escherichia coli strains (both NDM-producing carbapenemase strains). It can be confirmed as a carbapenemase-producing strain and its gene phenotype through the existing technology. All other materials used in this experiment can be obtained commercially.

[0101] 2. Experimental method

[0102] According to the recommendations of CLSI (Clinical and Laboratory Standards Institute) M07-A10 (2015 edition), the minimum inhibitory concentration (MIC) of meropenem and avibactam against clinical isolates was determined by the Broth-mi...

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PUM

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Abstract

The invention belongs to the technical field of medicines, relates to an antibiotic combination containing Avibactam and an application of the antibiotic combination, provides an application of Avibactam or pharmaceutically acceptable salt and carbapenems antibiotics to preparation of medicines for treating or preventing bacterial infection, particularly an application of the Avibactam to preparation of medicines for treating infection caused by escherichia coli, pseudomonas aeruginosa, klebsiella pneumoniae, baumanii and enterobacter aerogenes so as to solve the problem of drug resistance of the carbapenems antibiotics.

Description

technical field [0001] The invention relates to an antibacterial composition containing avibactam and its use, in particular, the invention relates to a composition containing avibactam and carbapenem antibiotics and its use. Background technique [0002] Avibactam (NXL-104) is a new type of β-lactamase inhibitor. The specificity of amidase production, Yang Fan et al. pointed out in the article "The new β-lactamase inhibitor Avibactam and its compound preparation worth looking forward to. Journal of Third Military Medical University, 2013,35(23):2498-2501" Avibactam can inhibit group A (including ESBLs and KPC enzymes), group C (mainly AmpC enzyme) and some group D β-lactamases (such as OXA-48), but usually cannot inhibit group B metallo-β-lactams Enzyme, the structure of avibactam is shown in formula I. [0003] [0004] Avibactam has almost no antibacterial activity, but combined with cephalosporin antibiotics can effectively restore or enhance its activity. The comp...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61K31/431A61K31/407A61K31/4196A61P31/04
CPCA61K31/407A61K31/4196A61K31/431A61K31/439A61P31/04A61K2300/00Y02A50/30
Inventor 程兴栋唐晓闻徐文卫李其德张爱明田心张喜全朱袁兴
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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