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Preparation method of high-strength antioxidation chitosan/polydopamine composite hydrogel

A technology of composite hydrogel and polydopamine, applied in the field of natural polymer chemistry, can solve the problems of weak mechanical properties, no anti-oxidation, limited application scope, etc., and achieves low cost, excellent product performance, good anti-oxidation and Effects of pH Responsiveness

Active Publication Date: 2019-09-17
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the hydrogels formed by traditional chitosan acidic aqueous solutions through physical and chemical methods have weak mechanical properties and no oxidation resistance, which limits the application range of such materials in food and medical materials.

Method used

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  • Preparation method of high-strength antioxidation chitosan/polydopamine composite hydrogel
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  • Preparation method of high-strength antioxidation chitosan/polydopamine composite hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A physically cross-linked chitosan hydrogel, the preparation method of which is as follows:

[0037] Prepare 95 grams of LiOH, KOH, urea and H 2 O Alkaline solvent mixed at a mass ratio of 5:7:8:80, 5 g of chitosan powder was added to the above-mentioned alkaline solvent and stirred for 5 min to disperse, frozen at -30°C, and then stirred and thawed at room temperature. The completely thawed solution was centrifuged at 5° C. at 7000 rpm for 10 minutes to defoam to obtain a clear and transparent 5 wt % chitosan alkaline solution. Place it in denatured alcohol for 24 hours to regenerate, and wash with water to obtain physically cross-linked chitosan hydrogel. Using a universal testing machine, the test rate is 0.5 mm / min, and the hydrogel compressive strength is measured to be 2.4 MPa, and the breaking strain is 82%.

Embodiment 2

[0039] A physically cross-linked chitosan / polydopamine composite hydrogel, the preparation method of which is as follows:

[0040] Prepare 95 grams of LiOH, KOH, urea and H2 O Alkaline solvent mixed at a mass ratio of 5:7:8:80, 5 g of chitosan powder was added to the above-mentioned alkaline solvent and stirred for 5 min to disperse, frozen at -30°C, and then stirred and thawed at room temperature. The completely thawed solution was centrifuged at 5° C. at 7000 rpm for 10 minutes to defoam to obtain a clear and transparent 5 wt % chitosan alkaline solution. Then add 0.5 gram of dopamine hydrochloride in this chitosan alkaline solution, stir at room temperature for 30 minutes, centrifugal defoaming, place in 5 ℃ of refrigerators and refrigerate for 24 hours, obtain dark brown chitosan / polydopamine alkaline fluid, place it It was regenerated in industrial alcohol for 24 hours, and washed with water to obtain a physically cross-linked chitosan / polydopamine composite hydrogel. Us...

Embodiment 3

[0042] A chitosan hydrogel of physicochemical crosslinking, its preparation method is as follows:

[0043] Prepare 95 grams of LiOH, KOH, urea and H 2 O Alkaline solvent mixed at a mass ratio of 5:7:8:80, 5 g of chitosan powder was added to the above-mentioned alkaline solvent and stirred for 5 min to disperse, frozen at -30°C, and then stirred and thawed at room temperature. The completely thawed solution was centrifuged at 5° C. at 7000 rpm for 10 minutes to defoam to obtain a clear and transparent 5 wt % chitosan alkaline solution. Then add 1.5mL epichlorohydrin to the chitosan alkaline solution, stir at room temperature for 30 minutes, centrifuge and defoam, and place it in a 5°C refrigerator for 24 hours to obtain the chitosan alkaline pregel, which is placed in Regenerated in industrial alcohol for 24 hours, and washed with water to obtain physicochemically cross-linked chitosan hydrogel. Using a universal testing machine, the test rate is 0.5 mm / min, and the hydrogel ...

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Abstract

The invention belongs to the technical field of natural polymer chemistry and in particular discloses a preparation method of a high-strength antioxidation chitosan / polydopamine composite hydrogel. Basic components of the composite hydrogel comprise chitosan and polydopamine. The method comprises the following steps: taking a mixed aqueous solution of LiOH, KOH and urea as a solvent, adding the chitosan into the solvent, and performing freeze thawing to obtain an alkaline chitosan solution; adding an appropriate amount of dopamine hydrochloride and / or epoxy chloropropane, stirring pregel, performing coagulation in water, a 70% alcohol aqueous solution or an industrial alcohol, and performing washing so as to obtain the hydrogel. The hydrogel disclosed by the invention has excellent mechanical properties, antibacterial activity and oxidation resistance, and is non-toxic, harmless, high in safety and biodegradable. The hydrogel disclosed by the invention has wide application prospects in the fields of medicines, cosmetics, environmental protection and the like, and the production process is simple, convenient and pollution-free.

Description

technical field [0001] The invention relates to the technical field of natural polymer chemistry, in particular to a preparation method of a high-strength anti-oxidation chitosan / polydopamine composite hydrogel. Background technique [0002] Chitosan, also known as deacetylated chitin, is obtained by deacetylation of chitin that exists widely in nature. Its chemical name is polyglucosamine (1-4)-2-amino-B-D glucose, and its molecular formula is (C 6 h 11 NO 4 )n. Chitin widely exists in the shells of crustaceans, and is the second largest natural polymer in terms of storage capacity after cellulose. Chitin with a degree of deacetylation greater than 55% is usually called chitosan. Chitosan has the advantages of wide source of raw materials, good biocompatibility, and easy degradation. However, the hydrogels formed by traditional chitosan acidic aqueous solutions through physical and chemical methods have weak mechanical properties and no oxidation resistance, which limi...

Claims

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Application Information

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IPC IPC(8): B01J13/00
CPCB01J13/0065
Inventor 张爱清蒋志伟
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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