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Terahertz ATR spectrum rapid measurement device and method for single-layer living cell

A terahertz, living cell technology, applied in measurement devices, material analysis by optical means, instruments, etc., can solve problems such as restricting development and large volume, and achieve the effects of no interference fringes, high sensitivity, and shortened measurement time intervals.

Pending Publication Date: 2019-08-30
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, based on the experimental method of dual optical paths, the volume of the experimental device is relatively large.
The above problems directly limit the application of living cells in terahertz time-domain spectroscopy, and restrict its development in scientific research, medical diagnosis and other fields.

Method used

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  • Terahertz ATR spectrum rapid measurement device and method for single-layer living cell

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Embodiment 1

[0028] A fast measurement device for terahertz ATR spectra of single-layer living cells, see figure 1 , The device includes: a terahertz photoconductive radiation source 1, a first terahertz off-axis parabolic mirror 2, a second terahertz off-axis parabolic mirror 3, a total reflection prism 4, a silicon dish structure with a silicon wafer at the bottom 5 ( Including: a single layer of living cells 6, cell culture medium 7), a third terahertz off-axis parabolic mirror 8, a fourth terahertz off-axis parabolic mirror 9, and a terahertz photoconductive detector 10.

[0029] The terahertz photoconductive radiation source 1 is focused and incident on the upper surface of the silicon wafer through the first terahertz off-axis parabolic mirror 2, the second terahertz off-axis parabolic mirror 3, and the total reflection prism 4. The single layer of living cells 6 interacts with the cell culture medium 7. The terahertz wave carrying sample information is detected by the third terahertz o...

Embodiment 2

[0032] A fast measurement method of terahertz ATR spectra based on a single layer of living cells, the method includes the following steps:

[0033] 1) Cultivate the cells to be tested in a silicon dish structure 5 of the same specification, and after the cells have adhered to the wall, the silicon dish to be tested is closely attached to the upper surface of the total reflection prism 4;

[0034] 2) After the terahertz photoconductive radiation source 1 passes through the first terahertz off-axis parabolic mirror 2, divergent light is transformed into parallel light transmission; after the terahertz wave passes through the second terahertz off-axis parabolic mirror 3, it is transmitted by parallel light Transmitting into convergent light; terahertz is incident on the inclined surface of the total reflection prism 4, passes through the upper surface of the total reflection prism 4, and is focused and incident on the silicon wafer at the bottom of the silicon dish structure 5, and oc...

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Abstract

The invention discloses a terahertz ATR (Attenuated Total Reflection) spectrum rapid measurement device and method for a single-layer living cell. An ATR photoconductive radiation source is focused onthe upper surface of a silicon dish after passing through a first terahertz off-axis parabolic mirror, a second terahertz off-axis parabolic mirror and a total reflection prism, and interacts with asingle-layer living cell and a cell culture solution in the silicon dish; the terahertz wave carrying sample information is detected by a third terahertz off-axis parabolic mirror, a fourth terahertzoff-axis parabolic mirror and a terahertz photoconductive detector to achieve the spectral measurement of the sample to be measured; and transmitting the detection signal to a computer analysis system, and obtaining the dielectric response information of a living cell sample in the terahertz wave band through the Fourier spectrum transformation principle. According to the method, cells are cultured in a plurality of silicon dish structures, and the silicon dish structures are arranged on the upper surface of the total reflection prism, so that the method is simple to operate, and the rapid detection of the terahertz spectrum of the single-layer cells is really achieved; and moreover, the measurement time interval of the background and the sample signal is small, and the error range of theexperimental result is obviously reduced.

Description

Technical field [0001] The invention relates to the field of terahertz attenuated total reflectance (ATR) time-domain spectroscopy, and in particular to a rapid measurement device and method for terahertz ATR spectra of a single layer of living cells. Background technique [0002] Terahertz (Terahertz, THz for short, 1THz=10 12 Hz) waves refer to electromagnetic waves with frequencies ranging from 0.1THz-10THz, with wavelengths ranging from 0.03mm to 3mm, which is the electromagnetic spectrum region between far-infrared light and microwaves. It has many unique properties, such as transient, broadband, low energy and so on. Therefore, THz wave spectroscopy technology has great application prospects and application value in life sciences, medical detection and other fields. Especially the measurement of terahertz spectroscopy of various cells has become a research hotspot. [0003] The current common single-layer cell terahertz spectroscopy detection methods are divided into transmi...

Claims

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Application Information

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IPC IPC(8): G01N21/552
CPCG01N21/552
Inventor 王与烨姜智南徐德刚刘宏翔姚建铨
Owner TIANJIN UNIV
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