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Calcium phosphate bioceramics compounded with collagen, and preparation method and usage method thereof

A technology of calcium phosphate ceramics and bioceramics, used in tissue regeneration, coating, medical science, etc., to avoid aseptic inflammation and avoid side effects

Active Publication Date: 2019-08-30
SHANGHAI BIO LU BIOMATERIALS
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Problems solved by technology

Therefore there are technical reports to improve the mechanical properties of ceramic materials by material composite technology, and existing research is committed to developing and preparing collagen base or using it as the biomaterial of added phase as the repair of bone tissue, for example, foreign patent (WO93 / 12736) discloses a method for mineralizing collagen as bone tissue repair, but it is only applicable to bone tissue wound repair in non-load-bearing parts

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  • Calcium phosphate bioceramics compounded with collagen, and preparation method and usage method thereof

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[0036] An embodiment of the present invention provides a method for preparing calcium phosphate bioceramics composited with collagen, see figure 1 , figure 1 It is a flowchart of a method for preparing a collagen-composite calcium phosphate bioceramic according to an embodiment of the present invention. The preparation method of the collagen-composite calcium phosphate bioceramic includes:

[0037] Step S1: Screen the required calcium phosphate ceramic particles;

[0038] Step S2: configuring at least one concentration of collagen solution;

[0039] Step S3: According to the order of the concentration of all the collagen liquids obtained in step S2 from low to high, use the collagen liquids of corresponding concentrations to form a corresponding cross-linked collagen coating on the surface of the calcium phosphate ceramic particles. And when the concentration of all the collagen solutions in step S2 is two or more than two, the cross-linked collagen coating formed by using the coll...

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Abstract

The invention provides calcium phosphate bioceramics compounded with collagen as well as a preparation method and a usage method thereof. The preparation method of the calcium phosphate bioceramics compounded with collagen comprises the following steps: forming cross-linked collagen coating on surfaces of calcium phosphate bioceramics by using collagen solutions of which the concentrations are from low to high, thereby obtaining cross-linked collagen coating with which the surfaces of the calcium phosphate bioceramics are wrapped; carrying out mixing with a collagen solution, and carrying outfreeze-drying so as to obtain precursors of the calcium phosphate bioceramics compounded with collagen; and then, soaking the coating with a collagen solution, and carrying out freeze-drying so as toobtain the calcium phosphate bioceramics compounded with collagen which comprise collagen wrapping layers. The calcium phosphate bioceramics compounded with collagen prepared according to the technical scheme of the invention have improved repair ability and degradation performance, so that, aseptic inflammation caused by falling off of calcium phosphate ceramic particles in clinical use can be avoided; moreover, the calcium phosphate bioceramics compounded with collagen are plastic in shape and size as well as convenient to use, so that, many problems of bioceramics in clinical application can be solved.

Description

Technical field [0001] The invention relates to the field of biomedical materials, in particular to a calcium phosphate bioceramic compounded with collagen and a preparation and use method thereof. Background technique [0002] Bioceramics refers to a type of ceramic materials used for specific biological or physiological functions, directly used in the human body or fields related to the human body. As a bioceramic material, it needs to have good biocompatibility, mechanical ratio, affinity with biological tissues, anti-thrombosis, and stable physical and chemical properties after sterilization. Calcium Phosphate Bioceramics (CaP) has inorganic components similar to human bone tissues, and has a variety of excellent biological characteristics, and is widely used in orthopedics, stomatology, ophthalmology, plastic surgery, ENT, brain surgery and Bone tissue repair in the fields of tissue engineering. With the advancement of material manufacturing technology, the understanding a...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/24A61L27/12A61L27/10A61L27/56A61L27/34
CPCA61L27/10A61L27/12A61L27/24A61L27/34A61L27/50A61L27/56A61L2430/02C08L89/00
Inventor 卢建熙卢霄王臻金芳纯高旭姚宸维
Owner SHANGHAI BIO LU BIOMATERIALS
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