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Method for enriching and purifying cannabidiol

A technology for cannabidiol and cannabis, which is applied to macroporous adsorption resin adsorption, enrichment and purification of cannabidiol, column chromatography to purify cannabidiol, and microwave countercurrent extraction, can solve the problem of long time, low purity, and cost reduction, etc. problem, to achieve the effect of simple method, high purity and cost reduction

Pending Publication Date: 2019-08-23
DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The regeneration of macroporous resin is convenient and rapid, suitable for large-scale production, and the cost is greatly reduced. Most of the pigments and impurities are removed by water precipitation; Well, the heavy product is used later, so the product obtained by the present invention has high purity, significantly increases the content of active ingredients, and overcomes the shortcomings of conventional extraction methods such as low purity and long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: A kind of method utilizing microwave countercurrent extraction, macroporous adsorption resin adsorption, column chromatography to purify cannabidiol in cannabis, its steps are as follows:

[0028] (1) Take industrial hemp leaves, stems or roots and grind them to 40 mesh after drying, add 60% ethanol solution, extract microwave countercurrent under 400W, time 10min, 8 times the ratio of material to liquid, forward feed and reverse water .The flow of material and water is reverse continuous dynamic flow. The extract is layered with petroleum ether to remove fatty oil;

[0029] (2) After reclaiming ethanol to no alcohol, absorb the macroporous resin on the obtained solution, the model is DA201 resin, and the height-to-diameter ratio of the resin column is 8: 1;

[0030] (3) Under normal temperature and pressure, with a flow rate of 1BV / h, first elute with distilled water, and the elution volume is 3BV;

[0031] (4) Use 40%, 50%, 60%, 70%, 85%, 95% ethanol s...

Embodiment example 2

[0035] Implementation Case 2: A method for purifying cannabidiol in cannabis by using microwave countercurrent extraction, macroporous adsorption resin adsorption, and column chromatography, the steps are as follows:

[0036] (1) Take industrial hemp leaves, stems or roots and grind them to 50 mesh after drying, add 65% ethanol solution, extract microwave countercurrent at 500W, time 20min, 10 times the ratio of material to liquid, forward feed and reverse water .The flow of material and water is reverse continuous dynamic flow. The extract is layered with petroleum ether to remove fatty oil;

[0037] (2) After recovering ethanol to no alcohol, absorb the macroporous resin on the obtained solution, the model is D101 resin, and the height-to-diameter ratio of the resin column is 15:1;

[0038] (3) At normal temperature and pressure, with a flow rate of 2BV / h, first elute with distilled water, and the elution volume is 5BV;

[0039] (4) Elute with 40%, 50%, 60%, 70%, 85%, 95% ...

Embodiment example 3

[0043] Implementation Case 3: A method for purifying cannabidiol in cannabis by using microwave countercurrent extraction, macroporous adsorption resin adsorption, and column chromatography, the steps are as follows:

[0044] (1) Take industrial hemp leaves, stems or roots and grind them to 60 mesh after drying, add 70% ethanol solution, extract microwave countercurrent at 600W, time 30min, 12 times the ratio of material to liquid, forward feed and reverse water .The flow of material and water is reverse continuous dynamic flow. The extract is layered with petroleum ether to remove fatty oil;

[0045] (2) After recovering ethanol to no alcohol, absorb the macroporous resin on the obtained solution, the model is AB-8 resin, and the height-to-diameter ratio of the resin column is 12:1:

[0046] (3) At normal temperature and pressure, with a flow rate of 3BV / h, first elute with distilled water, and the elution volume is 5BV;

[0047] (4) Use 40%, 50%, 60%, 70%, 85%, 95% ethanol...

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Abstract

The invention belongs to the technical field of chemical industry, relates to a method for enriching and purifying cannabidiol, and particularly relates to a method for purifying cannabidiol by usingmicrowave countercurrent extraction, macroporous adsorption resin adsorption and column chromatography. The method has the following advantages: 1, the microwave extraction is adopted, ethanol is usedas a solvent, a part of fat oils is removed, the extraction time is greatly reduced, the production efficiency is improved, and the method is simple; 2, the macroporous resin regeneration is convenient and rapid, and is suitable for large production, the cost is greatly reduced, most impurities are removed by water elution, and the operation is simple; and 3, the macroporous resin and silica gelcolumn chromatography are combined, the separation and purification effect is good, and the product purity is greatly improved. The method adopts microwave countercurrent extraction, macroporous resinseparation and purification, and column chromatography to carry out further purification, the product purity is greatly improved, and finally the cannabisdiol with a content of more than 65% and thecannabisdiol final product with a content of more than 90% are obtained.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of chemical industry and relates to a method for enriching and purifying cannabidiol, in particular to a method for purifying cannabidiol by microwave countercurrent extraction, macroporous adsorption resin adsorption and column chromatography. [0003] Background technique: [0004] Industrial hemp refers to hemp with a tetrahydrocannabinol content of less than 0.3%. In my country, industrial hemp is called hemp, which is an annual herb of the genus Cannabis in the family Cannabinaceae. The industrial hemp that has been approved to grow legally is a variety with low toxic content. These industrial hemp (THC<0.3%) are considered to have no drug use value, but they are still a treasure. Their applications include at least textiles, papermaking, food, and medicine. , health, daily chemical, leather, automobile, construction, decoration, packaging and other fields, it is a classic means of production....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/68C07C37/72C07C37/82C07C39/23
CPCC07C37/004C07C39/23
Inventor 姚德坤李玉伟万莉姚德利
Owner DAXINGANLING LINGOBERRY BOREAL BIOTECH CO LTD
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