Selenium-containing chalcone derivative Compound 1, synthesis method thereof, and application of Compound 1 in nonalcoholic steatohepatitis-resistant drugs

A selenium chalcone, non-alcoholic technology, applied in the field of new compound preparation and medicine, can solve problems such as patent publications that have not yet been found, and achieve the effect of simple synthesis and purification methods

Active Publication Date: 2019-08-20
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Selenium-containing chalcone derivative Compound 1, synthesis method thereof, and application of Compound 1 in nonalcoholic steatohepatitis-resistant drugs
  • Selenium-containing chalcone derivative Compound 1, synthesis method thereof, and application of Compound 1 in nonalcoholic steatohepatitis-resistant drugs
  • Selenium-containing chalcone derivative Compound 1, synthesis method thereof, and application of Compound 1 in nonalcoholic steatohepatitis-resistant drugs

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Embodiment Construction

[0039] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0040] The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0041] A selenium-containing chalcone derivative Compound 1, the structural formula of the selenium-containing chalcone derivative Compound 1 is as follows:

[0042]

[0043] Preferably, the activity of the selenium-containing chalcone derivative Compound 1 on nonalcoholic steatohepatitis is evaluated at the cellular level, and the results show that the compound has anti-nonalcoholic steatohepatitis activity in vitro, and at the same time, the compound has anti-nonalcoholic steatohepatitis activity in vivo. The lev...

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Abstract

The invention relates to a selenium-containing chalcone derivative Compound 1. The structural formula of the selenium-containing chalcone derivative Compound 1 is shown in the description. The selenium-containing chalcone derivative Compound 1 has nonalcoholic steatohepatitis inhibition activity, and is simple to synthesize and purify. The Compound 1 has the nonalcoholic steatohepatitis inhibitionactivity, can be used for treating nonalcoholic steatohepatitis, and can be used for preparing nonalcoholic steatohepatitis-resistant drugs.

Description

technical field [0001] The invention belongs to the technical field of preparation of new compounds and medicines, in particular a selenium-containing chalcone derivative Compound 1 and its synthesis method and its application in anti-nonalcoholic steatohepatitis drugs. Background technique [0002] The biopharmaceutical activity of chalcone compounds is more obvious and effective and has a good plastic structure, which can be combined with different drug intermediates and receptors in organisms to exhibit its unique biological activities. For example: anti-gastric ulcer, anti-malarial, anti-bacterial, anti-allergic, anti-HIV, anti-cancer, anti-hair loss and trigger hair growth, scavenging free radicals to achieve anti-oxidation, lowering blood fat, lowering blood pressure, anti-nonalcoholic steatohepatitis, etc. [0003] Selenium is a multifunctional life nutrient. It is often used for more than 40 diseases such as tumor, cancer, Keshan disease, Kaschin-Beck disease, cardio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C391/02A61P1/16
CPCA61P1/16C07C391/02
Inventor 郁彭赵连波赵玙璠苗爱郝磊付玉鹏丁颖向岑芦逵滕玉鸥
Owner TIANJIN UNIV OF SCI & TECH
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