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Applications of Lactobacillus kefiri M11 in bacteriostasis and in the treatment of type 2 diabetes mellitus as an active ingredient of medicament

A technology of Lactobacillus kefir, active ingredients, applied in medical preparations containing active ingredients, pharmaceutical formulations, metabolic diseases, etc., can solve the problems of low surface hydrophobicity and poor bacteriostatic ability of lactic acid bacteria, and achieve excellent surface Hydrophobicity and cohesion, good bacteriostatic effect, good inhibitory effect

Active Publication Date: 2019-08-20
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention solves the problems of low surface hydrophobicity of existing lactic acid bacteria and poor antibacterial ability of lactic acid bacteria

Method used

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  • Applications of Lactobacillus kefiri M11 in bacteriostasis and in the treatment of type 2 diabetes mellitus as an active ingredient of medicament
  • Applications of Lactobacillus kefiri M11 in bacteriostasis and in the treatment of type 2 diabetes mellitus as an active ingredient of medicament
  • Applications of Lactobacillus kefiri M11 in bacteriostasis and in the treatment of type 2 diabetes mellitus as an active ingredient of medicament

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specific Embodiment approach 1

[0027] Specific embodiment one: the application of Lactobacillus kefiri M11 in this embodiment on antibacterial.

specific Embodiment approach 2

[0028] Embodiment 2: The application of Lactobacillus kefiri M11 in this embodiment as an active ingredient of a drug for treating type 2 diabetes.

specific Embodiment approach 3

[0029] Specific embodiment three: the difference between this embodiment and specific embodiment two is: Lactobacillus kefir is freeze-dried to make a bacterial preparation, and then used as an active ingredient of a drug for treating type Ⅱ diabetes, and the production of the bacterial preparation The method is as follows: Lactobacillus kefiri M11 is cultured in MRS medium to the logarithmic growth phase, then centrifuged, the supernatant is removed to keep the bacteria, and then skimmed milk, sucrose, and sodium alginate are added to the bacteria to mix, and after freezing The dry treatment can obtain the Lactobacillus kefir preparation; wherein, the weight ratio of the bacteria body to the skimmed milk, sucrose and sodium alginate is 100:6-7:1-2:1-2. Others are the same as in the second embodiment.

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Abstract

The invention discloses applications of lactobacillus kefir M11 in bacteriostasis and in the treatment of type 2 diabetes mellitus as an active ingredient of medicament. The invention solves the problems of low surface hydrophobicity and poor bacteriostasis ability of the existing lactic acid bacteria. The lactobacillus kefiriM11 of the invention has an obvious inhibitory effect on escherichia coli and staphylococcus aureus, with a good bacteriostatic effect. According to the invention, the lactobacillus kefir iM11 and a bacterial preparation thereof have excellent surface hydrophobicity and cohesion and a good adhesion ability to the intestinal tract, thus realizing a good blood sugar regulation ability in the application of type 2 diabetes mellitus. The invention has an obvious effect onalleviating symptoms of type 2 diabetes mellitus.

Description

technical field [0001] The invention relates to an application of Lactobacillus kefir. Background technique [0002] Lactobacillus is a symbiotic bacterium in the intestinal tract of animals, which can help digestion and the health of the human intestinal tract. Foods containing active Lactobacillus are often regarded as healthy foods. Usually Lactobacillus is added to yogurt and other fermented foods for human consumption. Regulation of the balance of flora in the gut. In the body, intestinal epithelial cells can secrete a substance (probably a protein or lipid teichoic acid), which is conducive to the colonization of probiotics such as Lactobacillus on the intestinal mucosa, thereby forming a bacterial film barrier and repelling pathogenic bacteria on the intestinal wall Adhesion on. At the same time, Lactobacillus can produce lactic acid, acetic acid and bacteriocins to inhibit the invasion of various pathogenic bacteria. Therefore, the use of Lactobacillus instead of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61K9/19A61P3/10
CPCA61K35/747A61K9/19A61P3/10Y02A50/30
Inventor 孟利
Owner HEILONGJIANG UNIV
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