Water-soluble mercaptan-terminated PEG-functionalized POSS cross-linking agent, preparation method and applications thereof

A water-soluble, functionalized technology, applied in the field of materials, to achieve the effect of improving the solubility and uniform distribution of POSS

Active Publication Date: 2019-08-16
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Copolymerization of hydrophilic PEG on hydrophobic POSS to prepare PEG-functionalized POSS macromers can effectively improve the water solubility of POSS, but most of the prepared POSS-PEG hydrogels still need to be prepared in organic solvents or mixed solvents. preparation

Method used

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  • Water-soluble mercaptan-terminated PEG-functionalized POSS cross-linking agent, preparation method and applications thereof
  • Water-soluble mercaptan-terminated PEG-functionalized POSS cross-linking agent, preparation method and applications thereof
  • Water-soluble mercaptan-terminated PEG-functionalized POSS cross-linking agent, preparation method and applications thereof

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Embodiment Construction

[0042] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0043] It should be noted that, in the case of no conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0044] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.

[0045] The invention provides a water-soluble thiol-terminated PEG functionalized POSS crosslinking agent, the p...

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Abstract

The invention relates to a water-soluble mercaptan-terminated PEG-functionalized POSS cross-linking agent, a preparation method and applications thereof, wherein the macromolecular polymer has a structure represented by the following formula defined in the specification. According to the present invention, the water-soluble mercaptan-terminated star-shaped macromolecular polymer POSS-PEG-SH can beused as a cross-linking agent to react with a compound containing a double bond and other functional groups so as to prepare hydrolytically degradable hydrogels, enzyme-sensitive hydrogels and otherhydrogels, and due to the introduction of the polyfunctional POSS nanoparticles, a plurality of cross-linking sites can be added during the gelation so as to effectively improve the mechanical properties of the hydrogel.

Description

technical field [0001] The invention relates to the technical field of materials, in particular to a water-soluble mercaptan-capped PEG functionalized POSS crosslinking agent and a preparation method and application thereof. Background technique [0002] Hydrogels, a class of flexible polymeric materials similar to natural extracellular matrix (ECM), are widely used as tissue engineering scaffolds and drug and gene delivery matrices due to their flexibility and hydrated form. Among them, poly(ethylene glycol) (PEG) hydrogel is one of the most widely studied and widely used flexible hydrogel materials, which has good biocompatibility, hydrophilicity, biodegradability, non-immunogenic Key properties such as sex and anti-protein adsorption; can be excreted through the kidneys. However, under certain conditions, the "softness" of hydrogels has become a disadvantage, especially when the mechanical strength of hydrogels is much lower than that of certain biological tissues. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/46C08G77/392C08L71/02C08L83/12C08J3/24A61L27/52A61L27/38A61L27/26A61L27/50
CPCA61L27/26A61L27/38A61L27/50A61L27/52C08G77/392C08G77/46C08J3/246C08J2371/02C08J2483/12C08L71/02C08L83/12
Inventor 卢翠芬刘斯举郭仁琦李鹤玲陈祖兴杨桂春聂俊琦王飞翼
Owner HUBEI UNIV
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