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Method for preparing hollow fiber catheter and bundled structure thereof for nerve repair

A fibrous catheter and nerve repair technology, applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of low production efficiency, allergic reaction, too thick, etc., and achieve the effect of easy operation, increased adhesion strength, and uniform inner diameter

Active Publication Date: 2021-06-01
南京邦鼎生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the above-mentioned electrospinning method is convenient to prepare the catheter, it needs to use organic solvents, and the residual solvent will cause allergic reactions or even toxicity after implantation.
Freeze-drying after the aqueous solution is poured into the mold also has the disadvantages of long time consumption and low efficiency
Although 3D printing may not use solvents, it is difficult to use smaller diameter nozzles to achieve continuous printing, and the production efficiency is low
The process of melt extrusion into tube can have the advantages of high efficiency and easy size control. However, the processing limit of the outer diameter of the inner die of the tube in the industry is at least 0.4mm. The catheter of this specification is still too thick for nerve repair and needs to be processed. Thinner tubes and / or more microscopic orientation structures on the tubes can effectively induce the regeneration and repair of nerve cells

Method used

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  • Method for preparing hollow fiber catheter and bundled structure thereof for nerve repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of Bundle Structure I for Nerve Repair

[0035] Specifically include the following steps:

[0036] 1. Preparation of Hydrogel Precursor Solution

[0037] Firstly, the water-soluble chitosan is made into a 2.5% (w / v) concentration solution, and the NHS-PCLPEG5000PCL-NHS is made into a 20 (w / v)% concentration solution.

[0038] 2. Preparation of hollow fiber with secondary orientation structure

[0039] 2.1 Select PCL (Mn=80,000) with elongation at break as the raw material, and extrude it on a pipe making machine to obtain a tubular product with an outer diameter of 0.6 mm and a wall thickness of 0.2 mm.

[0040] 2.2 Insert a 0.1mm-diameter 316L stainless steel wire into the middle of a tubular object of a certain length, apply a traction force on both ends of the tubular object in opposite directions, and perform "cold drawing" on the tubular object. "Cold drawing" causes the diameter of the tubular object to shrink and the thickness Thin until...

Embodiment 2

[0047] Example 2: Preparation of Bundle Structure II for Nerve Repair

[0048] Specifically include the following steps:

[0049] 1. Preparation of Hydrogel Precursor Solution

[0050] First, the water-soluble chitosan was made into a 2.5% (w / v) concentration solution, and the NHS-PCLPEG5000PCL-NHS (Mn=7000) was made into a 20 (w / v)% concentration solution.

[0051] 2. Preparation of hollow fiber with secondary orientation structure

[0052] 2.1 Select a blend of four-arm branched PCL (Mn=76,000) and PCL-poly (L-lysine) as a raw material, and extrude it on a tube machine to obtain a tube with an outer diameter of 0.6 mm and a wall thickness of 0.2 mm.

[0053] 2.2 Insert a 0.2mm-diameter 316L stainless steel wire into the middle of a tubular object of a certain length, apply reverse traction force at both ends of the tubular object, and perform "cold drawing" on the tubular object. "Cold drawing" makes the tubular object begin to shrink in diameter and change in thickness. ...

Embodiment 3

[0058] Example 3: Preparation of Bundle Structure III for Nerve Repair

[0059] Specifically include the following steps:

[0060] 1. Preparation of Hydrogel Precursor Solution

[0061] Prepare four-arm PEG5000PCL-NHS and four-arm PEG5000PCL-NH respectively 2 The concentration is 10% (w / t) PBS solution.

[0062] 2. Preparation of hollow fiber with secondary orientation structure

[0063] 2.1 Select the mixture of PCL (Mn=80,000) and VB6 as the raw material, and extrude it on a pipe making machine to obtain a pipe with an outer diameter of 0.6mm and a wall thickness of 0.2mm.

[0064] 2.2 Insert a 0.1mm-diameter 316L stainless steel wire into the middle of a tubular object of a certain length, apply reverse traction force at both ends of the tubular object, and perform "cold drawing" on the tubular object. "Cold drawing" causes the diameter of the tubular object to shrink and the thickness to change. Thin until the tube is tightly wrapped on the outer surface of the steel w...

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Abstract

The present invention provides a method for preparing a hollow fiber catheter for nerve repair and a bundled structure thereof, which includes: preparing a mixed material containing at least one biodegradable polymer with an elongation at break of 30-1000% into an inner diameter of ≥0.3 mm tube; insert the rigid fiber into the tube and apply traction on both ends of the tube at normal temperature and pressure until the tube tightly covers the rigid fiber; remove the rigid fiber to obtain a hollow fiber catheter; use ammonia plasma to treat the hollow fiber The catheter is surface-treated; and then at least two surface-treated hollow fiber catheters are bonded into a bundle using biodegradable hydrogel to obtain a bundled structure for nerve repair. The method of the present invention can quickly and accurately prepare hollow fibers of different specifications, avoid the use of solvents, and produce bundled structures with a more microscopic orientation structure.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing a hollow fiber conduit for nerve repair and a bundled structure thereof. Background technique [0002] Due to the inhibitory environment of nerve regeneration after central nervous system injury, there is currently no effective clinical treatment, which causes great physical and psychological burdens on patients and their families. Synthesizing nerve conduits with specific materials and implanting them in damaged sites to induce regeneration of nerve cells is currently an effective way to repair central nervous system injuries. Among the materials for synthetic nerve repair catheters, the first generation of non-degradable materials is represented by silica gel. Although the silicone tube can show a good recovery effect on nerve sensation and movement in a short period of time, it cannot exchange substances with the outside world, nor can it be used by t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/50A61L27/54A61L27/58A61F2/02
CPCA61F2/02A61L27/18A61L27/20A61L27/50A61L27/54A61L27/58A61L2300/254A61L2300/412A61L2300/414A61L2300/428A61L2430/32C08L5/08C08L77/04C08L67/04C08L71/02
Inventor 万玉青
Owner 南京邦鼎生物科技有限公司
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