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A kind of psoralen total flavonoid extract and its preparation method and application

A technology of psoralen and total flavonoids, which is applied in the field of medicine, can solve the problems affecting the clinical application of psoralen flavonoids extract and cannot completely remove the toxic components of bakuchiol, so as to improve the safety of use, improve safety, The effect of high production efficiency

Active Publication Date: 2021-10-08
SHANGHAI UNIV OF T C M
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  • Abstract
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Problems solved by technology

[0009] Along with the in-depth research on the preparation method of psoralen flavonoids extract, the content of bakuchiol, psoralen and isopsoralen in the prepared psoralen total flavonoids extract is also greatly reduced, but the current In the psoralen total flavonoids extract obtained by the preparation method, the single content of bakuchiol, psoralen and isopsoralen can only be controlled at about 1% at most, and bakuchiol cannot be completely removed , psoralen, isopsoralen and other toxic ingredients have affected the clinical application of psoralen flavonoid extract

Method used

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  • A kind of psoralen total flavonoid extract and its preparation method and application
  • A kind of psoralen total flavonoid extract and its preparation method and application
  • A kind of psoralen total flavonoid extract and its preparation method and application

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Embodiment 1

[0037] Embodiment 1: Preparation of psoralen total flavonoids extract

[0038] a) Add petroleum ether (petroleum ether at 60-90°C) to degrease twice after crushing the psoraleae medicinal material (it can be degreased at room temperature, and the degreasing time is 6-12 hours each time, or reflux degreasing, every reflux time 1~2 hour), the weight of the sherwood oil that adds each time is 8 times of the weight of psoralen medicinal material, filters, obtains dregs;

[0039] b) The medicinal residue after petroleum ether degreasing is extracted twice with 80wt% ethanol aqueous solution under reflux, and the weight of the ethanol aqueous solution added for each extraction is 8 times of the medicinal residue weight, and the extracts are combined and concentrated under reduced pressure until there is no ethanol smell, Obtain ethanol extract;

[0040] c) dispersing the ethanol extract in water to obtain a suspension, and extracting the obtained suspension with an equal volume of ...

Embodiment 2

[0054] Embodiment 2: Anti-obesity effect test on mice induced by high-fat diet

[0055] 2.1 Experimental drug: the total flavonoids of psoralen was prepared by the above preparation method, and mixed with high-fat feed for administration. 0.5%.

[0056] 2.2 Experimental animals: 32 male 6-week-old C57BL / 6 mice were selected, and they were adaptively fed for one week. They were randomly divided into 8 groups according to body weight, namely, the model control group, the low-dose group of total psoralen flavonoids, and the total psoralen flavonoids group. High-dose flavone group; another 8 6-week-old male C57BL / 6 mice (normal mice of the same genetic strain) were selected as the normal control group; body weight and food intake were recorded every two days, and animal weight, food intake and physiological conditions were observed Changes; NMR body composition analyzer was used to analyze the body fat and muscle of the mice to observe the changes in the fat and muscle compositio...

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Abstract

The invention discloses an extract of total flavonoids of psoraleae and its preparation method and application. The total flavonoids extract of psoraleae is obtained by separating and extracting flavonoids from psoraleae medicinal material. The total content of index components is higher than 50%, and the flavonoid index components include: psoralen dihydroflavone, neopsoralen isoflavone, isopsoralen chalcone, psoralen dihydroflavone methyl ether, Boralen, Bakuchiol A, Bakuchiol Chalcone; and Free of Psoralen, Isopsoralen, and Bakuchiol. Experiments show that: the safety of the total flavonoids of psoraleae extract provided by the present invention is significantly improved, and has a significant weight loss effect, and is expected to be used for the preparation of medicines for the treatment and / or prevention of obesity. Compared with the prior art, it has achieved Significant progress and unexpected effects are of great significance to the research and development of psoralen pharmaceutical preparations with clinical application value.

Description

technical field [0001] The invention relates to an extract of total flavonoids of psoraleae and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] With the rapid development of China's economy and the continuous improvement of living standards, the number of obese people has risen rapidly, and China has become the second most obese country in the world. Obesity is a chronic metabolic disease with complex and diverse pathogenesis, and it can cause a variety of diseases, including type 2 diabetes, cardiovascular disease, hypertension, and dyslipidemia. The ways to treat obesity mainly include diet control, exercise enhancement, drug therapy and surgery. [0003] Currently, the U.S. Food and Drug Administration (FDA) has approved five drugs for long-term weight management, including the lipase inhibitor orlistat, the human glucagon-like peptide-1 (GLP-1) analog lila Glutide, norepinephrine reuptake inhibitor phe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/487A61P3/04A61K131/00
CPCA61K36/487A61K2236/333A61K2236/35A61K2236/39A61K2236/55
Inventor 郭夫江李医明刘静雯赵圆圆黄诚
Owner SHANGHAI UNIV OF T C M
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