Bimodal excitation cell system based on ultrasonics and electromagnetics

Abstract

A bimodal excitation cell system based on ultrasonics and electromagnetics belongs to the field of medical equipment. The system consists of a power module, a signal generating module, a driving amplification module, an ultrasonic excitation module, a magnetic excitation module and a detection module. The signal generating module transmits a pulse signal to the driving amplification module; the pulse signal is directly transmitted to the ultrasonic excitation module and the detection signal module after processed by the driving amplification module; the detection signal module is used for detecting the quality of the signal output at any time; the power module supplies power to the ultrasonic excitation module and the magnetic excitation module; the magnetic excitation module generates a magnetic field and acts on the cell excitation operation with the ultrasonic excitation module together. The system overcomes the limitation of single modal excitation cells, and can further increase the proliferation and the activity of the cells, thereby providing sufficient seed cells with good activity for autologous transplantation and providing more hope for treatment of traumatic paraplegia.

Description

technical field [0001] The invention relates to a dual-mode excitation cell system based on ultrasound and electromagnetics, which belongs to the field of medical equipment. Background technique [0002] Spinal cord injury (Spinal Cord Injury, SCI), as the most serious orthopedic traumatic disease with the most complications, is highly disabling and fatal, and the treatment methods for SCI are extremely limited, and its cure rate is extremely low. For spinal cord injury, bone marrow mesenchymal stem cells (BMSCs) have great application potential, which can bring positive effects to SCI patients in various aspects. After spinal cord injury, transplanted BMSCs have multiple effects on nerve regeneration, such as immune regulation and prevention of glial formation; can promote the integration of grafts with host tissues, and support the regeneration process through the secretion of cytokines and growth factors; It can secrete a large amount of NTFs, promote axon regeneration a...

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Problems solved by technology

At the same time, the clinical application of BMSCs also has limitations: it is generally believed that autologous BMSCs need to be selected for in vivo transplantation to repair SCI, but most of the bone marrow is hematopoietic stem cells, and the proportion of BMSCs is very small, only 0.001%-0.01%

Low-frequency pulsed ultrasound (LIPUS) and low-frequency electromagnetic fields (LFEMF), as physical stimulators, are effective auxiliary means to promote cell proliferation and differentiation, but the amount and activity of cells after stimulation cannot be obtained. ensure

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