A kind of small molecular toxin isolated and purified from the crude venom of Edenia grandis and its application

A technology for separation and purification, and it is applied in the application, peptide, biocide and other directions to achieve the effect of strong effect and reliable results.

Active Publication Date: 2022-04-15
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, there is no report on the selective effect of these acetylpolyamine small molecules on insect sodium channels

Method used

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  • A kind of small molecular toxin isolated and purified from the crude venom of Edenia grandis and its application
  • A kind of small molecular toxin isolated and purified from the crude venom of Edenia grandis and its application
  • A kind of small molecular toxin isolated and purified from the crude venom of Edenia grandis and its application

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Embodiment Construction

[0029] The present invention provides a small molecular toxin isolated and purified from the crude venom of E. grandis, the small molecule toxin isolated and purified from the crude venom of E. Ammonium small-molecule toxin, the relative molecular weight is 757.5112, nuclear magnetic resonance structure analysis, the molecular formula of the small-molecule toxin isolated and purified from the crude venom of Arachnid grandis is C 36 h 64 o 5 N 13 , whose structural formula is:

[0030]

[0031] The application of the small-molecule toxin isolated and purified from the crude venom of E. grandina provided by the present invention in insecticides or in neurobiological reagents and / or medicines, especially to block or completely block insect sodium ion channels way of application as a pesticide. When the small-molecule toxin isolated and purified from the crude venom of E. macula completely blocks the insect sodium ion channel, the concentration of the small-molecule toxin i...

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Abstract

The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small-molecule toxin isolated and purified from the crude venom of E. grandis, and its application. The small-molecule toxin separated and purified from the crude venom of E. grandis is a quaternary ammonium small-molecule toxin. The relative molecular weight is 757.5112, and the nuclear magnetic resonance structure analysis shows that the molecular formula of the small molecular toxin isolated and purified from the crude venom of Arachnid grandis is C 36 h 64 o 5 N 13 , The present invention provides a small molecular toxin isolated and purified from the crude venom of E. grandina, which has selective activity on insects, is less affected by pH, has stronger effect and more stable effect, and its application.

Description

technical field [0001] The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small-molecule toxin and its application, in particular to a small-molecule toxin separated and purified from the crude venom of E. grandis, and its application. Background technique [0002] The large-bellied garden spider (Araneus ventricosus) is a medium-sized spider that feeds on insects, and belongs to the phylum Arthropoda, Araneus, Aranea, Orbidae, and Orb genus in classification. The arachnid is one of the most widely distributed spiders in the world, and its venom contains a large number of toxic components that can anesthetize or kill insects. Explore the structural and functional characteristics of these small-molecule toxins isolated and purified from the crude venom of E. grandis, and screen out precursor molecules that may be used as neurobiological research tool reagents, drugs and insecticides. At present, there are very few studies on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/078A01N47/44A01P7/04
CPCC07K5/06139A01N47/44
Inventor 段志贵刘凯
Owner HUNAN NORMAL UNIVERSITY
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