The use of saipinin in the preparation of antifungal drug sensitizer

The technology of an antifungal drug and dipicrin, which is applied in the field of biomedicine, can solve the problems of interference propagation and growth, tumor cell death, etc., and achieves the effects of convenient acquisition, strong synergy and high safety.

Active Publication Date: 2021-08-13
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In a series of basic researches, it has been confirmed that saponin can induce tumor cell death and interfere with its dissemination and growth. At present, saponin has been widely studied in the fields of tumor biomolecules, but its antifungal properties The relationship between drugs has not been reported in relevant research

Method used

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  • The use of saipinin in the preparation of antifungal drug sensitizer
  • The use of saipinin in the preparation of antifungal drug sensitizer
  • The use of saipinin in the preparation of antifungal drug sensitizer

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Embodiment Construction

[0017] The present invention will now be described in detail with reference to the embodiments, but the implementation of the present invention is not limited thereto.

[0018] The reagents and raw materials used in the present invention are commercially available or can be prepared according to literature methods. In the following examples, the experimental methods without specific conditions are usually in accordance with conventional conditions or in accordance with the conditions suggested by the manufacturer. Unless otherwise stated, percentages and parts are by volume.

[0019] 1. Experimental materials

[0020] 1. Drugs and reagents

[0021] Fluconazole was purchased from SigmaAldrich Company in the United States, and crude furapicrin was purchased from TOCRIS Company in the United Kingdom, all of which were stored at -40 °C; dimethyl sulfoxide (DMSO) was purchased from SigmaAldrich Company in the United States; ultra-clean water was purchased from Japan Net Water ma...

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Abstract

The present invention relates to the technical field of medical biological detection, and provides the use of syringin in the preparation of antifungal drug sensitizers, the antifungal drug sensitizer with syringin as an active ingredient, and an antifungal combined preparation. In the present invention, it is determined through experiments that when fluconazole is combined with pyridin, the FICI of all experimental strains is less than or equal to 0.50, which shows a strong synergistic effect, and at the same time reduces the MIC value of fluconazole by 2-16 It improves the sensitivity of fluconazole to cryptococcus, which is not only beneficial to reduce the clinical dosage, but also helps to slow down the phenomenon of high drug resistance rate of cryptococcus, which is a useful exploration for clinical antifungal infection.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, and relates to a new use of furapicrin, in particular to the use in the preparation of antifungal drug sensitizers. Background technique [0002] The increasing number of immunocompromised people, including HIV infection, malignancy, radiotherapy and chemotherapy, organ or stem cell transplantation, and autoimmune diseases, as well as the abuse of broad-spectrum antibiotics, long-term use of immunosuppressants, and newer treatments such as catheter-based interventions The morbidity and mortality of invasive fungal infections (cryptococcal disease) have risen rapidly due to factors such as the continuous expansion of operating techniques. With the continuous use of antifungal drugs, the phenomenon of fungal drug resistance has become more and more common in the past 10 years, and the degree of drug resistance has become higher and higher. In contrast, in the past 20 years, there has be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/10A61K31/4196
CPCA61K31/352A61K31/4196A61P31/10A61K2300/00
Inventor 张超雷岩方伟朱信霖廖万清
Owner SHANGHAI CHANGZHENG HOSPITAL
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