Non-invasive portal vein pressure gradient measurement method based on medical image

Abstract

The invention relates to a non-invasive portal vein pressure gradient measurement method based on a medical image. A portal vein simulation model with a scientific and reasonable structure, no clinical invasive surgery, good effect, low cost and easy implementation is used. Through the experiment, the simulation study of the population with cirrhosis and a normal group is carried out in the model,and the non-invasive portal vein pressure gradient measurement method based on the medical image is provided. The results show that the patient with cirrhosis has higher stress than the normal groupunder the method. In the experiment, as an end area decreases, the relative pressure increases correspondingly, an appropriate area is found to divide the thresholds the two types of population, whichis beneficial to the subsequent simulation calculation. The method uses three-dimensional modeling to combine with a hemodynamic simulation calculation method to analyze a continuous high-pressure principle of portal vein, avoids the high cost and personal injury caused by experiment or blind design, and has certain guiding significance for clinical detection of portal hypertension.

Description

technical field [0001] The invention relates to a non-invasive portal vein pressure gradient measurement method based on medical images. The pressure gradient is obtained mainly by simulating the three-dimensional reconstruction of human CT scans, so as to predict whether there is portal hypertension. Background technique [0002] Liver cirrhosis has become a global concern. Liver cirrhosis progresses from liver fibrosis, and early diagnosis of liver fibrosis is fundamental. The staging of fibrosis is crucial for the prognosis and management of patients with liver disease. Liver biopsy is considered the gold standard for the staging and diagnosis of liver fibrosis. But a liver biopsy is an invasive procedure with some painful and potentially fatal complications. [0003] Portal vein thrombosis is relatively common in patients with liver cirrhosis, with an incidence rate of 0.6% to 26%. Thrombosis in the splenic vein or superior and inferior mesenteric veins may occur concu...

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Problems solved by technology

[0005] (1) The methods of non-invasive diagnosis of PHT all use non-specific indicators and are difficult to quantify. The relationship between these non-specific indicators and portal pressure is not completely parallel, and cannot be explained by simple linearization;

[0006] (2) The research scope of hemodynamics is limited to the main portal vein, and an effective portal vein branch model has not been established to analyze its pressure and velocity changes;

[0007] (3) The research on blood rheology is still in its infancy, and the change of blood viscosity and the reduction of red blood cell deformability can change the resistance of portal vein vessels and hemodynamic indicators

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